SRP8009

GITRL, Soluble mouse

recombinant, expressed in HEK 293 cells, FLAG^® tagged, >90% (SDS-PAGE)

• 동의어(들): AITRL, EGF-like protein 9, Glucocorticoid-induced TNF receptor ligand, TNFSF18
• UNSPSC 코드: 12352202
• NACRES: NA.32

속성

• 생물학적 소스: mouse
• 재조합: expressed in HEK 293 cells
• 태그: FLAG^® tagged
• 분석: >90% (SDS-PAGE)
• 양식: liquid
• 분자량: ~22 kDa by SDS-PAGE
• 포장: pkg of 50 μg
• 저장 조건: avoid repeated freeze/thaw cycles
• 농도: ≥0.2 mg/mL
• 불순물: <0.1 EU/μg endotoxin, tested
• 색상: clear
• UniProt 수납 번호: Q7TS55
• 배송 상태: wet ice
• 저장 온도: −20°C
• 유전자 정보: mouse ... Tnfsf18(240873)

설명

일반 설명

GITRL (Glucocorticoid-induced TNF receptor ligand) is expressed on dendritic cells (DC), monocytes, macrophages, B cells, activated T cells, endothelial cells, osteoclasts and various healthy non-lymphoid tissues (e.g. testis). GITRL is constitutively expressed and released as soluble form by solid tumors and various hematopoietic malignancies. GITRL causes differentiation of osteoclasts, activation of macrophages, but also alteration of carcinoma and leukemia cells and influences apoptosis. Binding to GITR is important in regulating T cell proliferation and TCR-mediated apoptosis. GITRL is implicated in development of autoimmune diseases and in the immune response against infectious pathogens and tumors.

물리적 형태

Solution in 10 mM glycine, pH 10.0.

기타 정보

The extracellular domain of mouse GITRL (aa 45-173) is fused at the N-terminus to a FLAG^®-tag.

법적 정보

FLAG is a registered trademark of Merck KGaA, Darmstadt, Germany

안전성 정보

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable