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Merck
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Key Documents

SRP8026

Sigma-Aldrich

Annexin V human

recombinant, expressed in E. coli, GST tagged, ≥95% (SDS-PAGE)

동의어(들):

Annexin A5, Calphobindin I, EC 2.7.1.23, Endonexin II, Placental anticoagulantprotein I

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About This Item

UNSPSC 코드:
12352200
NACRES:
NA.32

생물학적 소스

human

재조합

expressed in E. coli

태그

GST tagged

분석

≥95% (SDS-PAGE)

형태

lyophilized

분자량

~52 kDa

포장

pkg of 100 μg

저장 조건

avoid repeated freeze/thaw cycles

기술

activity assay: suitable

색상

white

UniProt 수납 번호

배송 상태

wet ice

저장 온도

−20°C

유전자 정보

human ... ANXA5(308)

일반 설명

Annexin V is a member of the annexin family of calcium and membrane-binding proteins that have anticoagulatory and anti-inflammatory properties. The encoded protein is 320 amino acid long and is folded into four domains, each having five α-helices, forming a superhelical globular structure. The ANX5 gene is mapped to human chromosome 4q26-q28 and spans a length of 28kb containing 13 exons and 12 introns.

애플리케이션

Annexin V has been used to examine phosphorylation activity of ChaK1 (channel-kinase 1).

생화학적/생리학적 작용

Annexins are a family of water-soluble proteins that bind to membranes and phospholipids in a calcium-dependent manner. They participate in several cellular functions, such as membrane fusion and cytoskeletal interaction. Annexin V is a potent anticoagulant and serves as a voltage-gated calcium channel when bound to membrane in vitro. It is found to inhibit phospholipase A2 and protein kinase C.

물리적 형태

Lyophilized from PBS, pH 7.4.

재구성

Reconstitute with 100 μL deionized water.

기타 정보

Recombinant human annexin V fused to a GST-tag.

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


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