T104

Tropisetron monohydrochloride

solid, ≥98% (HPLC)

• 동의어(들): 1H-Indole-3-carboxylic acid (3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl ester monohydrochloride, 3-Tropanylindole-3-carboxylate monohydrochloride, ICS-205,930, Navoban
• 실험식(Hill 표기법): C₁₇H₂₀N₂O₂ · HCl
• CAS Number: 105826-92-4
• Molecular Weight: 320.81
• MDL number: MFCD00210221
• UNSPSC 코드: 12352200
• PubChem Substance ID: 24278133
• NACRES: NA.77

속성

• 분석: ≥98% (HPLC)
• 양식: solid
• solubility: H₂O: >10 mg/mL
• 주관자: Novartis
• 저장 온도: 2-8°C
• SMILES string: Cl[H].CN1C2CCC1CC(C2)OC(=O)c3c[nH]c4ccccc34
• InChI: 1S/C17H20N2O2.ClH/c1-19-11-6-7-12(19)9-13(8-11)21-17(20)15-10-18-16-5-3-2-4-14(15)16;/h2-5,10-13,18H,6-9H2,1H3;1H
• InChI key: XIEGSJAEZIGKSA-UHFFFAOYSA-N
• 유전자 정보: human ... CHRNA3(1136) , CHRNA4(1137) , CHRNB2(1141) , CHRNB4(1143) , HTR3A(3359) , HTR3B(9177) , HTR3C(170572) , HTR3D(200909) , HTR3E(285242) ; rat ... Chrna7(25302) , Drd2(24318) , Htr1a(24473) , Htr3a(79246)

설명

애플리케이션

Tropisetron monohydrochloride was used as a standard to determine the tropisetron in human plasma using HPLC method with UV detection.

생화학적/생리학적 작용

3-Tropanylindole-3-carboxylate hydrochloride is a selective 5-HT₃ serotonin receptor antagonist.

Selective 5-HT₃ serotonin receptor antagonist.

Tropisetron a selective serotonin 5-HT₃ receptor antagonist is used mainly as an antiemetic to treat nausea and vomiting following chemotherapy . In the treatment of fibromyalgia syndrome (FMS) tropisetron reduced not only pain perception but also had a favourable effect on cardiac dysfunction during treatment.

특징 및 장점

This compound is featured on the Acetylcholine Receptors (Nicotinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)