추천 제품
일반 설명
Transferrin is a bilobed glycoprotein containing an N-terminal lobe and a C-terminal lobe. Each of these domains is divided into two sub-domains and within the inter subdomain cleft is the metal-binding site. A single transferrin molecule can bind to two ferric ions. Apo-transferrin is an iron-free form.
애플리케이션
Apo-transferrin has been shown to strongly inhibit bacterial adhesion to biomaterials including polystyrene, polymethylmethacrylate, and silicone. Inhibition was seen at twenty micrograms/ml in culture medium.
apo-Transferrin human has been used in Dulbecco′s Modified Eagle Medium/Nutrient Mixture F-12 to culture:
- pancreatic ductal adenocarcinoma (PDAC) cell lines
- oligodendrocytes
- renal proximal tubule epithelial cells (RPTEC/TERT1) cells
생화학적/생리학적 작용
Transferrin transports iron through receptor-mediated endocytosis. The iron transport mechanism occurs in the endothelial cells of the blood-brain barrier. Transferrin maintains iron homeostasis and is an iron-associated marker. Reduced levels of transferrin are observed in severe COVID-19 conditions. It may bind to other molecules apart from iron, hence it can be used in targeted drug delivery.
기타 정보
Non-heme iron-transport protein.
면책조항
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
가장 최신 버전 중 하나를 선택하세요:
시험 성적서(COA)
Lot/Batch Number
이미 열람한 고객
Camila Campos-Escamilla et al.
International journal of molecular sciences, 22(24) (2021-12-25)
Human serum transferrin (Tf) is a bilobed glycoprotein whose function is to transport iron through receptor-mediated endocytosis. The mechanism for iron release is pH-dependent and involves conformational changes in the protein, thus making it an attractive system for possible biomedical
Catherine Claise et al.
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 116, 74-79 (2021-12-25)
Mounting evidence links hyperinflammation in gravely ill patients to low serum iron levels and hyperferritinemia. However, little attention has been paid to other iron-associated markers such as transferrin. The aim of this study was to investigate the association of different
Reza Ardehali et al.
Artificial organs, 26(6), 512-520 (2002-06-20)
Apo-transferrin (apo-Tf), the iron deficient form of Tf, has been identified previously as a potent inhibitor of Staphylococcus epidermidis adhesion to polyurethane surfaces. In this study, the ability of apo-Tf to suppress the adhesion of two other strains of bacteria
Agostina Nardone et al.
Cell and tissue banking, 10(4), 301-308 (2009-02-03)
In breast cancer, various clinical parameters are assessed to define clinical stage and thus obtain a more accurate prognosis. However, banks of tumor tissues are an important source of material for studies of risk of recurrence and of features governing
Jacob M Smigiel et al.
Molecular cancer research : MCR, 15(4), 478-488 (2017-01-06)
Pancreatic ductal adenocarcinoma (PDAC) is referred to as a silent killer due to the lack of clear symptoms, a lack of early detection methods, and a high frequency of metastasis at diagnosis. In addition, pancreatic cancer is remarkably resistant to
자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..
고객지원팀으로 연락바랍니다.