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Merck
모든 사진(1)

문서

T4382

Sigma-Aldrich

apo-Transferrin human

powder, ≥98% (agarose gel electrophoresis)

동의어(들):

Human transferrin, Siderophilin

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About This Item

CAS Number:
EC Number:
MDL number:
UNSPSC 코드:
12352202
NACRES:
NA.75

생물학적 소스

human

Quality Level

분석

≥98% (agarose gel electrophoresis)

형태

powder

분자량

76-81 kDa

철 함량

≤0.005%

기술

cell culture | mammalian: suitable

불순물

HIV and HBsAg, source material tested negative

solubility

H2O: 50 mg/mL

UniProt 수납 번호

배송 상태

wet ice

저장 온도

−20°C

유전자 정보

human ... TF(7018)

유사한 제품을 찾으십니까? 방문 제품 비교 안내

일반 설명

Apo-transferrin human is a glycoprotein, possessing homologous carboxyl and amino domain. Both the domain binds to one molecule of iron. Only 30% of transferrin is saturated with iron in the amino domain. Apo-transferrin in human is encoded by the gene TF which is localized on human chromosome 3q22.1.

애플리케이션

Apo-Transferrin human has been used:
  • to determine the competitive binding of bismuth to albumin and transferrin by fast performance liquid chromatography (FPLC)
  • to study titanium-transferrin complex by electrochemical method
  • in the preparation of transferrin solution and in the formation of conjugates with ruthenium-complexes for cellular viability studies

생화학적/생리학적 작용

Apo-transferrin is an iron transport protein. The concentration of transferrin in blood plasma is about 35 μM. Transferrin also functions in the transport of therapeutic, diagnostic and toxic ions like Ga3+, Ru3+ and Al3+. Polymorphism in TF gene has pathological implications in Parkinson′s disease.
Apo-transferrin is required for the survival and differentiation of oligodendroglial cells.

기타 정보

Non-heme iron-transport protein.

결합

Similar to T 2252

면책조항

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3


시험 성적서(COA)

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이 제품을 이미 가지고 계십니까?

문서 라이브러리에서 최근에 구매한 제품에 대한 문서를 찾아보세요.

문서 라이브러리 방문

Junko Iijima et al.
Fukushima journal of medical science, 67(2), 64-70 (2021-08-11)
Spontaneous intracranial hypotension (SIH) is caused by cerebrospinal fluid (CSF) leakage. Patients with SIH experience postural headaches, nausea, etc., due to CSF hypovolemia. Imaging studies and clinical examinations, such as radioisotope (RI) scintigraphy, are useful for diagnosing SIH. However, 20-30%
Pooled analysis of iron-related genes in Parkinson's disease: association with transferrin
Rhodes SL, et al.
Neurobiology of Disease, 62, 172-178 (2014)
New polydentate Ru (III)-Salan complexes: Synthesis, characterization, anti-tumour activity and interaction with human serum proteins
Matos CP, et al.
Inorgorganica Chimica Acta, 394, 616-626 (2013)
Li-Jin Chan et al.
Nature communications, 12(1), 1538-1538 (2021-03-23)
Plasmodium vivax preferentially invades reticulocytes and recognition of these cells is mediated by P. vivax Reticulocyte Binding Protein 2b (PvRBP2b) binding to human Transferrin receptor 1 (TfR1) and Transferrin (Tf). Longitudinal cohort studies in Papua New Guinea, Thailand and Brazil
Direct electrochemistry of the Ti (IV)-transferrin complex: Probing into the transport of Ti (IV) by human serum transferrin
Shen M, et al.
Electrochemical Communications, 13(2), 114-116 (2011)

문서

Understand how transferrin affects serum-free cell culture systems, crucial for biomanufacturing heterologous proteins like monoclonal antibodies.

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