T2501

L-Thyroxine sodium salt pentahydrate

≥98% (HPLC), powder

• 동의어(들): 3-[4-(4-Hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]-L-alanine sodium salt, Sodium levothyroxine, T₄
• Linear Formula: HOC₆H₂I₂OC₆H₂I₂CH₂CH(NH₂)COONa · 5H₂O
• CAS Number: 6106-07-6
• Molecular Weight: 888.93
• Beilstein: 5721845
• EC Number: 200-221-4
• MDL number: MFCD00149110
• UNSPSC 코드: 51111800
• PubChem Substance ID: 24900041
• NACRES: NA.32

속성

• 생물학적 소스: synthetic (organic)
• 무균: non-sterile
• 분석: ≥98% (HPLC)
• 형태: powder
• mp: 207-210 (dec.) (lit.)
• solubility: 4 M NH₄OH in methanol: 50 mg/mL, clear to hazy, colorless to yellow
• 배송 상태: ambient
• 저장 온도: −20°C
• SMILES string: O.O.O.O.O.[Na+].N[C@@H](Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C([O-])=O
• InChI: 1S/C15H11I4NO4.Na.5H2O/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23;;;;;;/h1-2,4-5,12,21H,3,20H2,(H,22,23);;5*1H2/q;+1;;;;;/p-1/t12-;;;;;;/m0....../s1
• InChI key: JMHCCAYJTTWMCX-QWPJCUCISA-M
• 유전자 정보: mouse ... Cnr2(12802) ; rat ... Cnr1(25248)

설명

생화학적/생리학적 작용

L-Thyroxine (T₄) and triiodo-L-thyronine (T₃) are iodine-containing hormones produced from thyroglobulin in the thyroid follicular cells. The stimulation of metabolic rate and regulation of growth and development by these hormones appear to be due to their effects on DNA transcription and thus, protein synthesis.

제조 메모

L-Thyroxine sodium salt pentahydrate dissolves in 4 N NH4OH in methanol at 50 mg/ml to yield a clear to hazy, colorless to yellow solution.

안전성 정보

• 픽토그램: GHS08
• 신호어: Danger
• 유해 및 위험 성명서: H372
• 예방조치 성명서: P260 - P264 - P270 - P314 - P501
• Hazard Classifications: STOT RE 1
• 표적 기관: Thyroid,Cardio-vascular system,Kidney
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: Eyeshields, Gloves, type N95 (US)