T8516

Trifluoperazine dihydrochloride

≥99%, powder

• 동의어(들): 10-[3-(4-Methylpiperazin-1-yl)propyl]-2-(trifluoromethyl)-10H-phenothiazine dihydrochloride
• 실험식(Hill 표기법): C₂₁H₂₄F₃N₃S · 2HCl
• CAS Number: 440-17-5
• Molecular Weight: 480.42
• Beilstein: 3820024
• EC Number: 207-123-0
• MDL number: MFCD00012656
• UNSPSC 코드: 12352200
• PubChem Substance ID: 57654709
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥99%
• 양식: powder
• 색상: white to off-white
• mp: 243 °C (dec.) (lit.)
• solubility: ethanol: soluble 5 mg/mL; H₂O: soluble 50 mg/mL, clear, colorless to yellow; DMSO: soluble
• 저장 온도: −20°C
• SMILES string: Cl[H].Cl[H].CN1CCN(CCCN2c3ccccc3Sc4ccc(cc24)C(F)(F)F)CC1
• InChI: 1S/C21H24F3N3S.2ClH/c1-25-11-13-26(14-12-25)9-4-10-27-17-5-2-3-6-19(17)28-20-8-7-16(15-18(20)27)21(22,23)24;;/h2-3,5-8,15H,4,9-14H2,1H3;2*1H
• InChI key: BXDAOUXDMHXPDI-UHFFFAOYSA-N
• 유전자 정보: human ... DRD2(1813) , DRD3(1814) , DRD4(1815) , HTR2A(3356) , HTR2C(3358)

설명

애플리케이션

Trifluoperazine dihydrochloride has been used as a calmodulin kinase antagonist in cultured Aplysia californica neurons. Trifluoperazine dihydrochloride has also been used as a PMCA inhibitor in mouse duodenal tissues to block the transcellular active calcium flux.

Trifluoperazine dihydrochloride has been used:

• to inhibit clathrin-dependent endocytosis
• as a calmodulin kinase antagonist in cultured Aplysia californica neurons
• as a plasma membrane Ca²⁺-ATPase (PMCA) inhibitor in mouse duodenal tissues to block the transcellular active calcium flux

생화학적/생리학적 작용

Phenothiazine antipsychotic; D₂ dopamine receptor antagonist; inhibits calmodulin-dependent stimulation of 3′:5′-cyclic nucleotide phosphodiesterase; inhibits cAMP-gated cation channels.

Trifluoperazine dihydrochloride is useful in treating schizophrenia, disturbed behavior, severe anxiety, nausea and vomiting.

특징 및 장점

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

제조 메모

Trifluoperazine dihydrochloride dissolves in water at 50 mg/ml, with heat as required, and yields a clear, colorless to yellow solution. It is also soluble in DMSO and ethanol (5 mg/ml).

안전성 정보

• 픽토그램: GHS08,GHS07,GHS09
• 신호어: Danger
• 유해 및 위험 성명서: H302,H319,H336,H341,H372,H410
• 예방조치 성명서: P201 - P273 - P301 + P312 + P330 - P305 + P351 + P338 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Muta. 2 - STOT RE 1 - STOT SE 3
• 표적 기관: Central nervous system, Eyes
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• 개인 보호 장비: dust mask type N95 (US), Eyeshields, Gloves