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Merck
모든 사진(1)

주요 문서

UC430

Sigma-Aldrich

1′-Hydroxymidazolam

≥97% (HPLC), powder

동의어(들):

8-Chloro-6-(2-fluorophenyl)-1-hydroxymethyl-4H-imidazo[1,5a][1,4]benzodiazepine

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About This Item

실험식(Hill 표기법):
C18H13ClFN3O
CAS Number:
Molecular Weight:
341.77
MDL number:
UNSPSC 코드:
12161501
PubChem Substance ID:
NACRES:
NA.77

제품명

1′-Hydroxymidazolam,

양식

powder

Quality Level

약물 제어

regulated under CDSA - not available from Sigma-Aldrich Canada

색상

white to off-white

저장 온도

2-8°C

SMILES string

OCc1ncc2CN=C(c3ccccc3F)c4cc(Cl)ccc4-n12

InChI

1S/C18H13ClFN3O/c19-11-5-6-16-14(7-11)18(13-3-1-2-4-15(13)20)22-9-12-8-21-17(10-24)23(12)16/h1-8,24H,9-10H2

InChI key

QHSMEGADRFZVNE-UHFFFAOYSA-N

일반 설명

1′-Hydroxymidazolam is the metabolite of midazolam.

애플리케이션

1′-Hydroxymidazolam (1′-OHMDZ) can be used for assessing Cyp3a11 enzyme activity as well as for pharmacokinetic (PK) study of midazolam.
CYP3A4 metabolite of midazolam.

생화학적/생리학적 작용

1′-Hydroxymidazolam is the major hydroxylated metabolite of Midazolam (MDZ), forms due to rapid and extensive metabolization of MDZ by the CYP 450 3A isoenzymes in the liver. The product contributes to the pharmacological impact of MDZ.

특징 및 장점

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

포장

Bottomless glass bottle. Contents are inside inserted fused cone.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

개인 보호 장비

Eyeshields, Gloves, type N95 (US)


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