Target Identification for Antibody Drug Discovery
Identify targets using the most comprehensive set
of genome-wide screening tools available.
Target discovery involves the identification of specific genes or proteins that play a key role in disease. We offer a complete set of genome-modifying screening tools, including CRISPR and shRNA modalities, to facilitate target identification for monoclonal antibody screening. These tools can be combined with a wide array of cellular and biochemical tools to fast-track target validation and therapeutic development.
Tools for Target Identification and Validation
Functional Genomics Screening Tools for Target Identification
Identify novel therapeutic targets using the most complete set of genome-wide functional genomics screening tools available.
- CRISPR screens for gene knockout, loss-of-function, gain-of-function, or combinations of gene perturbation methods
- Pooled CRISPR screening at single cell resolution for high content information centered around genome-wide transcriptome profiling for candidate genes
- RNAi libraries and RNAi single clones to quickly target and silence genes in target discovery
- Tools for NGS library preparation to facilitate the preparation of high quality DNA or RNA libraries
- Pooled single cell RNA sequencing (scRNA-seq) for higher throughput quantitative transcriptional profiling
- Custom oligos for genomics methods
In vitro Tools for Target Validation
Developing cellular assays for lead discovery requires the production of biologically relevant models for comprehensive assessment. Our premier in vitro solutions include assays, reagents, and cell culture tools designed to help researchers validate their screened targets and identify phenotypes. We provide a comprehensive range of disease-relevant cell lines to enable the development of tissue-specific models for drug screening. Our organoid portfolio includes both iPSC- and patient-derived organoids, enabling drug screening in highly biomimetic models supported by specialized media, reagents, and 3D cell culture plates. Maximize your lead discovery with our MultiScreen® HTS plates or use our Millicell® cell culture inserts and plates to create scalable 6-, 12-, 24-, or 96-well cell assay environments. Our immunoassay platform solutions and western blotting tools enable sensitive qualitative or quantitative detection of biomarkers on any scale.
Related Categories
ECACC repository cell lines, cancer cell lines, cellular models, and more.
Human primary cells, normal and disease state PBMCs, and immune cells.
Human iPSC-derived and patient-derived organoids for advanced cell culture.
Promoting natural, multidimensional growth for more relevant in vitro models.
Fluorescent dyes, probes, biosensors, and labeling technologies for cell imaging.
Reagents, consumables, and equipment for electrophoresis and detection.
Biomarker data you can trust for best next-step decisions.
Filtration plates for cell-based assays, ELISpot, ligand binding, and more.
Multiplexed scRNA-seq for gene expression analysis.
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