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109185

Sigma-Aldrich

Saccharin

≥98%

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Synonym(s):
2,3-Dihydroxy-1,2-benzisothiazol-3-one-1,1-dioxide, 2-Sulfobenzoic acid imide, o-Benzoic sulfimide
Empirical Formula (Hill Notation):
C7H5NO3S
CAS Number:
Molecular Weight:
183.18
Beilstein:
6888
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.22

Quality Level

Assay

≥98%

mp

226-229 °C (lit.)

solubility

H2O: soluble 1g in 290ml
acetone: soluble 1g in 12ml
alcohol: soluble 1g in 31ml
boiling water: soluble 1g in 25ml
glycerol: soluble 1g in 50ml
alcohol: very slightly soluble
chloroform: slightly soluble
diethyl ether: slightly soluble

SMILES string

O=C1NS(=O)(=O)c2ccccc12

InChI

1S/C7H5NO3S/c9-7-5-3-1-2-4-6(5)12(10,11)8-7/h1-4H,(H,8,9)

InChI key

CVHZOJJKTDOEJC-UHFFFAOYSA-N

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1 of 4

This Item
240931PHR1341S0040000
Saccharin ≥98%

Sigma-Aldrich

109185

Saccharin

Saccharin ≥99%

Sigma-Aldrich

240931

Saccharin

Saccharin Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1341

Saccharin

Saccharin European Pharmacopoeia (EP) Reference Standard

S0040000

Saccharin

mp

226-229 °C (lit.)

mp

226-229 °C (lit.)

mp

226-229 °C (lit.)

mp

226-229 °C (lit.)

solubility

H2O: soluble 1g in 290ml, acetone: soluble 1g in 12ml, alcohol: soluble 1g in 31ml, boiling water: soluble 1g in 25ml, glycerol: soluble 1g in 50ml, alcohol: very slightly soluble, chloroform: slightly soluble, diethyl ether: slightly soluble

solubility

acetone: 1g in 12mL(lit.), alcohol: 1g in 31mL(lit.), boiling water: 1g in 25mL(lit.)

solubility

-

solubility

-

Application

Saccharin was used in high performance liquid chromatographic method for the simultaneous separation and determination of acesulfame potassium, saccharine and aspartame. It was used in sweet preference test of rats.

Biochem/physiol Actions

Dietery administration of saccharin after N-methyl-N′-nitro-N-nitrosoguanidine promotes tumor development in rats.
A sweet tastant for mammals. A glycerol taste receptor binding site specific for glucose has been proposed in drosophila.

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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M Takahashi et al.
Gan, 75(6), 494-501 (1984-06-01)
Sodium chloride, saccharin sodium, phenobarbital sodium and aspirin were tested for tumor-promoting activity in the glandular stomach of rats after initiation with N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) coupled with administration of a high salt diet. Male outbred Wistar rats were given MNNG in
Anne Marie Vinggaard et al.
Toxicological sciences : an official journal of the Society of Toxicology, 85(2), 886-897 (2005-03-25)
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Journal of medicinal chemistry, 50(6), 1241-1253 (2007-02-28)
The screening of the inhibition capabilities of dye-like small molecules from a focused library against both human PRMT1 and Aspergillus nidulans RmtA is reported as well as molecular modeling studies (homology modeling, molecular docking, and 3-D QSAR) of the catalytic
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