184489

1,3-Dichloro-2-propanol

97%

• Synonym(s): Glycerol-α,γ-dichlorohydrin
• Linear Formula: (ClCH₂)₂CHOH
• CAS Number: 96-23-1
• Molecular Weight: 128.99
• Beilstein/REAXYS Number: 1732063
• EC Number: 202-491-9
• MDL number: MFCD00000951
• UNSPSC Code: 12352100
• PubChem Substance ID: 24851118
• NACRES: NA.22

Properties

• Quality Level: 100
• assay: 97%
• form: liquid
• refractive index: n20/D 1.483 (lit.)
• bp: 174.3 °C (lit.)
• mp: −4 °C (lit.)
• solubility: water: soluble 10 part; alcohol: miscible; diethyl ether: miscible
• density: 1.363 g/mL at 20 °C; 1.351 g/mL at 25 °C (lit.)
• functional group: chloro; hydroxyl
• SMILES string: OC(CCl)CCl
• InChI: 1S/C3H6Cl2O/c4-1-3(6)2-5/h3,6H,1-2H2
• InChI key: DEWLEGDTCGBNGU-UHFFFAOYSA-N

Description

General description

1,3-Dichloro-2-propanol is a food processing contaminant. Biotransformation of 1,3-dichloro-2-propanol to epichlorohydrin by the whole cells of recombinant Escherichia coli via resin-based in situ product removal has been investigated.

1,3-Dichloro-2-propanol is used as a pharmaceutical intermediate and solvent for paints, lacquers, and epoxy resins.

Application

1,3-Dichloro-2-propanol can be used as a reactant to synthesize:

• Hydroxyl-N-tosylcyclams via sodium ethoxide catalyzed cyclization reaction with di(poly)-N-tosylamides.
• (R)-Epichlorohydrin using biocatalysts.
• 1,3-dichloropropene, a soil fumigant, and synthetic glycerol.

It can also be used as an intermediate in the production of epoxy resins, as well as a solvent for hard resins and nitrocellulose.

Safety Information

• pictograms: GHS06,GHS08
• signalword: Danger
• hcodes: H301,H312,H350
• pcodes: P202 - P264 - P280 - P301 + P310 - P302 + P352 + P312 - P362 + P364
• Hazard Classifications: Acute Tox. 3 Oral - Acute Tox. 4 Dermal - Carc. 1B
• Storage Class: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• wgk_germany: WGK 3
• flash_point_f: 186.8 °F - closed cup
• flash_point_c: 86 °C - closed cup
• ppe: Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter