202673

Arsenic(III) oxide

99.995% trace metals basis

• Synonym(s): ATO, Diarsenic trioxide;, Arsenic trioxide, Arsenous acid
• Empirical Formula (Hill Notation): As₂O₃
• CAS Number: 1327-53-3
• Molecular Weight: 197.84
• EC Number: 215-481-4
• MDL number: MFCD00003433
• UNSPSC Code: 12161600
• eCl@ss: 38080102
• PubChem Substance ID: 24852110
• NACRES: NA.22

Properties

• Quality Level: 200
• assay: 99.995% trace metals basis
• form: powder
• reaction suitability: core: arsenic; reagent type: catalyst
• SMILES string: O=[As]O[As]=O
• InChI: 1S/As2O3/c3-1-5-2-4
• InChI key: IKWTVSLWAPBBKU-UHFFFAOYSA-N

Description

General description

Arsenic(III) oxide (ATO) is an inorganic form of arsenic that is used as a therapeutic compound for treating patients with acute promyelocytic leukemia (APL). Many drug-delivery methods are currently being developed using nanotechnology to overcome its poor bioavailability due to rapid clearance from blood.

Application

• Electrochemical detection applications: A study on La-based perovskites incorporated with functionalized carbon nanofibers highlights the use of arsenic trioxide for the electrochemical detection of roxarsone in water and food samples, providing a method to improve safety and environmental monitoring (John Felix MA et al., 2024).


• Antiproliferative effects in cancer research: Research demonstrates the inhibitory effects of arsenic trioxide, combined with metformin, on KG1a cell proliferation, suggesting its potential utility in developing antineoplastic strategies (Huang-Li WH et al., 2024).


• Environmental remediation: A review on manganese oxide-based materials for arsenic removal discusses the application of arsenic trioxide in environmental remediation, focusing on the effectiveness and advancements in arsenic decontamination technologies (Younas M et al., 2024).

Safety Information

• pictograms: GHS06,GHS08,GHS05,GHS09
• signalword: Danger
• hcodes: H300,H314,H350,H372,H410
• pcodes: P260 - P273 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 2 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1A - Eye Dam. 1 - Skin Corr. 1B - STOT RE 1
• target_organs: Respiratory system,Cardio-vascular system,Gastrointestinal tract
• Storage Class: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges