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233781

Sigma-Aldrich

Triisopropylsilane

98%

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Synonym(s):
TIS, Triisopropylhydrosilane, Tris(1-methylethyl)silane
Linear Formula:
[(CH3)2CH]3SiH
CAS Number:
Molecular Weight:
158.36
Beilstein:
1733718
MDL number:
PubChem Substance ID:
EC Index Number:
464-880-1
NACRES:
NA.22

Quality Level

Assay

98%

form

liquid

reaction suitability

reagent type: reductant

refractive index

n20/D 1.434 (lit.)

bp

84-86 °C/35 mmHg (lit.)

density

0.773 g/mL at 25 °C (lit.)

SMILES string

CC(C)[SiH](C(C)C)C(C)C

InChI

1S/C9H22Si/c1-7(2)10(8(3)4)9(5)6/h7-10H,1-6H3

Inchi Key

YDJXDYKQMRNUSA-UHFFFAOYSA-N

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1 of 4

This Item
278785429937250600
Triisopropylsilane 98%

Sigma-Aldrich

233781

Triisopropylsilane

Triisobutylsilane 99%

Sigma-Aldrich

278785

Triisobutylsilane

reaction suitability

reagent type: reductant

reaction suitability

-

reaction suitability

-

reaction suitability

reagent type: reductant

refractive index

n20/D 1.434 (lit.)

refractive index

n20/D 1.435 (lit.)

refractive index

n20/D 1.479 (lit.)

refractive index

-

bp

84-86 °C/35 mmHg (lit.)

bp

204-206 °C (lit.)

bp

70-75 °C/2 mmHg (lit.)

bp

-

density

0.773 g/mL at 25 °C (lit.)

density

0.764 g/mL at 25 °C (lit.)

density

0.887 g/mL at 25 °C (lit.)

density

-

Quality Level

200

Quality Level

100

Quality Level

100

Quality Level

100

General description

Triisopropylsilane (TIPS) is an organosilicon compound used as a reducing agent in organic synthesis due to its relatively low toxicity, ease of handling, and its ability to selectively reduce various functional groups. It is used in the presence of a Lewis acid such as titanium (IV) chloride to selectively reduce ketones and aldehydes to their corresponding alkanes and selective reduction of epoxides to the corresponding alcohols.

Application

Triisopropylsilane can be used as a reducing agent:
  • To synthesize 4-pyrrole phenylacyl peptide during solid-phase peptide synthesis.
  • In transition metal complex-catalyzed reaction of amides with hydrosilanes.
  • For the selective reduction of C-arylglucosides into β-C-aryl glucosides.
  • To facilitate the cleavage of acetamidomethyl (Acm), 4-methoxybenzyl (Mob), and tert-butyl (But) protecting groups from cysteine (Cys) residues in the presence of trifluoroacetic acid.
  • For the reduction of amides to corresponding amines in the presence of transition-metal catalysts.

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Description
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Pictograms

Flame

Signal Word

Warning

Hazard Statements

Hazard Classifications

Flam. Liq. 3

Storage Class Code

3 - Flammable liquids

WGK

WGK 3

Flash Point(F)

100.4 °F - closed cup

Flash Point(C)

38 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Kanicha Sa-ei et al.
Organic letters, 8(20), 4441-4443 (2006-09-22)
The catalytic, diastereoselective coupling of alpha-silyloxy aldehydes and alkynylsilanes catalyzed by a nickel(0) N-heterocyclic carbene complex provides an effective entry to anti-1,2-diols. The scope of couplings and extent of diastereoselection are excellent across a range of substrates.
E Gibula-Tarlowska et al.
Behavioural brain research, 372, 112043-112043 (2019-06-22)
Kissorphin (KSO) is a new peptide derived from kisspeptin-10. Previous study has indicated that this peptide displays neuropeptide FF (NPFF)-like anti-opioid activity. Herein, we examined the influence of KSO (1; 3, and 10 nmol, intravenously [i.v.]), on the rewarding action of
Transition-metal complex-catalyzed reduction of amides with hydrosilanes: a facile transformation of amides to amines
Mamoru I,et al.
Tetrahedron Letters, 42, 1945-1947 (2001)
Reduction of a 4-pyrrole phenylacyl-containing peptide with trifluoroacetic acid--triisopropylsilane--phenol--H2O during solid-phase peptide synthesis and its protein kinase C $\alpha$ inhibitory activity
Hwan J and Lee
Bioorganic & medicinal chemistry letters, 15, 2271-2274 (2005)
Tetrahedron Letters, 44, 7837-7840 (2003)

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