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D125407

Sigma-Aldrich

DIC

99%

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Synonym(s):
N,N′-Diisopropylcarbodiimide
Linear Formula:
(CH3)2CHN=C=NCH(CH3)2
CAS Number:
Molecular Weight:
126.20
Beilstein/REAXYS Number:
878281
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.22

Quality Level

assay

99%

form

liquid

reaction suitability

reaction type: Coupling Reactions

refractive index

n20/D 1.433 (lit.)

bp

145-148 °C (lit.)

density

0.815 g/mL at 20 °C (lit.)

application(s)

peptide synthesis

SMILES string

CC(C)N=C=NC(C)C

InChI

1S/C7H14N2/c1-6(2)8-5-9-7(3)4/h6-7H,1-4H3

InChI key

BDNKZNFMNDZQMI-UHFFFAOYSA-N

Gene Information

human ... EPHX2(2053)
mouse ... Ephx2(13850)

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1 of 4

This Item
38370D80002379115
DIC 99%

D125407

DIC

DIC purum, ≥98.0% (GC)

38370

DIC

DCC 99%

D80002

DCC

DCC 1.0 M in methylene chloride

379115

DCC

assay

99%

assay

≥98.0% (GC)

assay

99%

assay

-

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

-

reaction suitability

reaction type: Coupling Reactions

reaction suitability

reaction type: Coupling Reactions

reaction suitability

reaction type: Coupling Reactions

reaction suitability

reaction type: Coupling Reactions

refractive index

n20/D 1.433 (lit.)

refractive index

n20/D 1.433 (lit.)

refractive index

-

refractive index

-

bp

145-148 °C (lit.)

bp

145-148 °C (lit.)

bp

122-124 °C/6 mmHg (lit.)

bp

-

General description

DIC is an abbreviated form of N,N′-diisopropylcarbodiimide. It plays a role in the cyclization of N-(β-hydroxy)amides to form 2-oxazolines.

Application

Coupling reagent for peptide syntheses.
DIC (N,N′-Diisopropylcarbodiimide) has been used in combination with 1-hydroxy-7-azabenzotriazole (HOAt) for the coupling of amino acid with N-allylglycine to form N-allylpeptide.
Alternative to dicyclohexylcarbodiimide in peptide synthesis.

related product

signalword

Danger

Hazard Classifications

Acute Tox. 1 Inhalation - Eye Dam. 1 - Flam. Liq. 3 - Resp. Sens. 1 - Skin Sens. 1

Storage Class

3 - Flammable liquids

wgk_germany

WGK 3

flash_point_f

91.4 °F

flash_point_c

33 °C

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter


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Collection of Czechoslovak Chemical Communications, 59, 691-691 (1994)
Tetrahedron Letters, 35, 5981-5981 (1994)
Synthesis of 2-oxazolines mediated by N,N'-diisopropylcarbodiimide.
Crosignani S, et al.
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