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N-Methyl-N-(trimethylsilyl)trifluoroacetamide

synthesis grade

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Synonym(s):
N-Trimethylsilyl-N-methyl trifluoroacetamide, MSTFA
Linear Formula:
CF3CON(CH3)Si(CH3)3
CAS Number:
Molecular Weight:
199.25
Beilstein/REAXYS Number:
1941550
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.22

grade

for GC derivatization
synthesis grade

Quality Level

vapor density

>1 (vs air)

vapor pressure

8.8 mmHg ( 27 °C)

assay

≥98%

form

liquid

reaction suitability

reagent type: derivatization reagent
reaction type: Silylations

refractive index

n20/D 1.38 (lit.)

bp

130-132 °C (lit.)

density

1.075 g/mL at 25 °C (lit.)

storage temp.

2-8°C

SMILES string

CN(C(=O)C(F)(F)F)[Si](C)(C)C

InChI

1S/C6H12F3NOSi/c1-10(12(2,3)4)5(11)6(7,8)9/h1-4H3

InChI key

MSPCIZMDDUQPGJ-UHFFFAOYSA-N

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This Item
6947969478M7891
N-Methyl-N-(trimethylsilyl)trifluoroacetamide BioReagent, for silylations, LiChropur™

M7891

N-Methyl-N-(trimethylsilyl)trifluoroacetamide

Essential+ Grade
reaction suitability

reagent type: derivatization reagent
reaction type: Silylations

reaction suitability

reagent type: derivatization reagent
reaction type: Silylations

reaction suitability

reagent type: derivatization reagent
reaction type: Silylations

reaction suitability

-

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

form

liquid

form

liquid

form

liquid

form

liquid

density

1.075 g/mL at 25 °C (lit.)

density

1.075 g/mL at 25 °C (lit.)

density

-

density

1.07 g/mL at 25 °C (lit.), 1.075 g/mL at 25 °C (lit.)

refractive index

n20/D 1.38 (lit.)

refractive index

n20/D 1.38 (lit.), n20/D 1.380

refractive index

n20/D 1.378

refractive index

n20/D 1.38 (lit.)

General description

N-Methyl-N-(trimethylsilyl)trifluoroacetamide (MSTFA) is a derivatizing reagent. It can be used as alternatives to diazomethane.

Application

Silylating agent used to form volatile derivatives for GC-MS analysis.
Improved silylation procedure for simultaneous detection of steroid hormones 17-α-ethynylestradiol and estrone.

Other Notes

Reagent for trimethylsilyl.

related product

pictograms

FlameExclamation mark

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Flam. Liq. 3 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

3 - Flammable liquids

wgk_germany

WGK 3

flash_point_f

78.8 °F - closed cup

flash_point_c

26 °C - closed cup

ppe

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter


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An evaluation of derivatization procedures for the detection of beta(2)-agonists is presented. The study was performed with the beta(2)-agonists bambuterol, clenbuterol, fenoterol, formoterol, salbutamol, salmeterol and terbutaline. Different derivatizating agents were employed, aiming to obtain derivatives with high selectivity to
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