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450510

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Deuterium oxide

99.9 atom % D, contains 0.05 wt. % 3-(trimethylsilyl)propionic-2,2,3,3-d4 acid, sodium salt

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Synonym(s):
Heavy water, Water-d2
Empirical Formula (Hill Notation):
D2O
CAS Number:
Molecular Weight:
20.03
EC Number:
MDL number:
PubChem Substance ID:
NACRES:
NA.21

isotopic purity

99.9 atom % D

Quality Level

form

liquid

contains

0.05 wt. % 3-(trimethylsilyl)propionic-2,2,3,3-d4 acid, sodium salt

technique(s)

NMR: suitable

bp

101.4 °C (lit.)

mp

3.8 °C (lit.)

SMILES string

[2H]O[2H]

InChI

1S/H2O/h1H2/i/hD2

InChI key

XLYOFNOQVPJJNP-ZSJDYOACSA-N

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1 of 4

This Item
756822613428293040
Deuterium oxide 99.9 atom % D, contains 0.05 wt. % 3-(trimethylsilyl)propionic-2,2,3,3-d4 acid, sodium salt

450510

Deuterium oxide

Deuterium oxide filtered, 99.8 atom % D

756822

Deuterium oxide

Deuterium oxide 70 atom % D

613428

Deuterium oxide

Deuterium oxide 99.9 atom % D, contains 0.75 wt. % 3-(trimethylsilyl)propionic-2,2,3,3-d4 acid, sodium salt

293040

Deuterium oxide

technique(s)

NMR: suitable

technique(s)

HPLC: suitable, bio NMR: suitable, protein expression: suitable

technique(s)

bio NMR: suitable

technique(s)

NMR: suitable

form

liquid

form

liquid

form

liquid

form

liquid

mp

3.8 °C (lit.)

mp

3.8 °C (lit.)

mp

3.8 °C (lit.)

mp

3.8 °C (lit.)

bp

101.4 °C (lit.)

bp

101.4 °C (lit.)

bp

101.4 °C (lit.)

bp

101.4 °C (lit.)

isotopic purity

99.9 atom % D

isotopic purity

99.8 atom % D

isotopic purity

70 atom % D

isotopic purity

99.9 atom % D

General description

Deuterium oxide (D2O, heavy water) is deuterated water containing 0.05wt.% 3-(trimethylsilyl)propionic-2,2,3,3-d4 acid, sodium salt. It is safe and inexpensive source of deuterium (D) for the D/H exchange reactions. The equilibrium constant for the exchange of deuterium between hydrogen (H) and D2O molecules has been determined. Reports suggest that gelatin gels prepared in D2O show higher rigidity than gels prepared in water. The influence of temperature on the heat capacity of deuterium in crystalline and liquid state was studied calorimetrically and its melting point, enthalpy and entropy of fusion were determined. Its utility as a potential therapeutic agent in treating human pancreatic cancer has been studied.

application

Deuterium oxide may be used in the following processes:
  • As an NMR solvent.
  • Preparation of β-deuterated alcohols.
  • For the adsorption of neutrons in atomic reactors.
  • Deuterium transfer agent in combination with hexamethyldisilane in the preparation of 1,2-dideuterioalkenes from alkynes.

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Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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Andrew J Jezewski et al.
Frontiers in cellular and infection microbiology, 11, 730413-730413 (2021-10-05)
Glycolysis controls cellular energy, redox balance, and biosynthesis. Antiglycolytic therapies are under investigation for treatment of obesity, cancer, aging, autoimmunity, and microbial diseases. Interrupting glycolysis is highly valued as a therapeutic strategy, because glycolytic disruption is generally tolerated in mammals.
Yu-Hsi Lin et al.
Nature metabolism, 2(12), 1413-1426 (2020-11-25)
Inhibiting glycolysis remains an aspirational approach for the treatment of cancer. We have previously identified a subset of cancers harbouring homozygous deletion of the glycolytic enzyme enolase (ENO1) that have exceptional sensitivity to inhibition of its redundant paralogue, ENO2, through
NMR spectroscopy of saccharide-doped PAGAT dosimeters.
Skyt PS, et al.
Journal of Physics. Conference Series, 573 (2015)
The Exchange Reaction of Hydrogen and Deuterium Oxide.
Crist RH and Dalin GA
J. Chem. Phys. , 2(8), 548-548 (1934)
Gelatin gels in deuterium oxide.
Oakenfull D and Scott A.
Food Hydrocolloids, 17(2), 207-210 (2003)

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