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475696

Sigma-Aldrich

Poly(ethylene glycol) diglycidyl ether

average MN 500, cross-linking reagent amine reactive, glycidyl

Synonym(s):

Polyethylene glycol, Diepoxy PEG, PEG diglycidyl ether, Polyoxyethylene bis(glycidyl ether)

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About This Item

Linear Formula:
C3H5O2-(C2H4O)n-C3H5O
CAS Number:
UNSPSC Code:
12162002
NACRES:
NA.23

product name

Poly(ethylene glycol) diglycidyl ether, average Mn 500

mol wt

average Mn 500

Quality Level

reaction suitability

reagent type: cross-linking reagent
reactivity: amine reactive

refractive index

n20/D 1.47

Ω-end

epoxy

α-end

epoxy

polymer architecture

shape: linear
functionality: homobifunctional

storage temp.

2-8°C

InChI

1S/C8H14O4/c1(9-3-7-5-11-7)2-10-4-8-6-12-8/h7-8H,1-6H2

InChI key

AOBIOSPNXBMOAT-UHFFFAOYSA-N

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General description

Poly(ethylene glycol) diglycidyl ether (PEGDGE) shows highly solubility in water. Hence, it easily undergoes hydrolysis followed by ring cleavage reaction in aqueous solution, yielding hydroxyl group. PEGDGE combines with proteins covalently or non-covalently. PEGDGE is widely used in chemical industries for cross linking and surface modifier.

Application

The high solubility of PEGDGE has been successfully employed to immobilize glucose oxidase, d-amino acid oxidase and glutamate oxidase. It may be used as a component for the development of microelectrode biosensors to detect hydrogen peroxide and nitric oxide.

Storage Class

10 - Combustible liquids

wgk_germany

WGK 3

flash_point_f

386.6 °F - closed cup

flash_point_c

197.00 °C - closed cup

ppe

Eyeshields, Gloves


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Direct electrochemistry and electrocatalysis of hemoglobin on a glassy carbon electrode modified with poly (ethylene glycol diglycidyl ether) and gold nanoparticles on a quaternized cellulose support. A sensor for hydrogen peroxide and nitric oxide.
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Articles

Scaffold patterning with poly(ethylene glycol)-based hydrogels for cell presence in 2D and 3D environments on photoactive substrates.

Progress in biotechnology fields such as tissue engineering and drug delivery is accompanied by an increasing demand for diverse functional biomaterials. One class of biomaterials that has been the subject of intense research interest is hydrogels, because they closely mimic the natural environment of cells, both chemically and physically and therefore can be used as support to grow cells. This article specifically discusses poly(ethylene glycol) (PEG) hydrogels, which are good for biological applications because they do not generally elicit an immune response. PEGs offer a readily available, easy to modify polymer for widespread use in hydrogel fabrication, including 2D and 3D scaffold for tissue culture. The degradable linkages also enable a variety of applications for release of therapeutic agents.

Designing biomaterial scaffolds mimicking complex living tissue structures is crucial for tissue engineering and regenerative medicine advancements.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

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