MilliporeSigma
All Photos(1)

Documents

764205

Sigma-Aldrich

Alkyne-PEG4-maleimide

90% (HPLC)

Sign Into View Organizational & Contract Pricing

Synonym(s):
Acetylene-PEG4-maleimide
Empirical Formula (Hill Notation):
C18H26N2O7
Molecular Weight:
382.41
MDL number:
PubChem Substance ID:
NACRES:
NA.22

Quality Level

assay

90% (HPLC)

form

liquid

reaction suitability

reaction type: click chemistry
reagent type: cross-linking reagent

mp

62-67 °C

functional group

alkyne
maleimide

storage temp.

−20°C

SMILES string

O=C(N1CCC(NCCOCCOCCOCCOCC#C)=O)C=CC1=O

InChI

1S/C18H26N2O7/c1-2-8-24-10-12-26-14-15-27-13-11-25-9-6-19-16(21)5-7-20-17(22)3-4-18(20)23/h1,3-4H,5-15H2,(H,19,21)

InChI key

GHEBECZRHJXPTL-UHFFFAOYSA-N

Compare Similar Items

View Full Comparison

Show Differences

1 of 4

This Item
764191760668764019
Alkyne-PEG4-maleimide 90% (HPLC)

764205

Alkyne-PEG4-maleimide

Dibenzocyclooctyne-maleimide for Copper-free Click Chemistry

760668

Dibenzocyclooctyne-maleimide

reaction suitability

reaction type: click chemistry, reagent type: cross-linking reagent

reaction suitability

reaction type: click chemistry, reagent type: cross-linking reagent

reaction suitability

reaction type: click chemistry, reagent type: cross-linking reagent

reaction suitability

reaction type: click chemistry, reagent type: linker

form

liquid

form

liquid

form

solid

form

paste

mp

62-67 °C

mp

-

mp

-

mp

-

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

functional group

alkyne

functional group

NHS ester, alkyne

functional group

maleimide

functional group

NHS ester

Application

Alkyne-PEG4-maleimide has been used for modification of Csy containing bacterial collagens by introducing alkyne moiety to enable it for further chemical modification.
Heterobifunctional crosslinker enabling the connection of an azide containing compound or biomolecule to one with a thiol. The maleimide group will react preferentially with thiols to form a covalent adduct and the terminal alkyne will react with azides via copper-catalyzed 1,3-dipolar cycloaddition click chemistry. The hydrophilic PEG spacer adds to the water solubility of this reagent, allowing for easy modification cysteine containing biomolecules such as antibodies, proteins and peptides with the terminal alkyne. The PEG spacer also reduces aggregation of modified proteins stored in solution by adding hydrophilic character.

related product

Product No.
Description
Pricing

Storage Class

10 - Combustible liquids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Documents related to the products that you have purchased in the past have been gathered in the Document Library for your convenience.

Visit the Document Library

Difficulty Finding Your Product Or Lot/Batch Number?

Product numbers are combined with Pack Sizes/Quantity when displayed on the website (example: T1503-25G). Please make sure you enter ONLY the product number in the Product Number field (example: T1503).

Example:

T1503
Product Number
-
25G
Pack Size/Quantity

Additional examples:

705578-5MG-PW

PL860-CGA/SHF-1EA

MMYOMAG-74K-13

1000309185

enter as 1.000309185)

Having trouble? Feel free to contact Technical Service for assistance.

Lot and Batch Numbers can be found on a product's label following the words 'Lot' or 'Batch'.

Aldrich Products

  • For a lot number such as TO09019TO, enter it as 09019TO (without the first two letters 'TO').

  • For a lot number with a filling-code such as 05427ES-021, enter it as 05427ES (without the filling-code '-021').

  • For a lot number with a filling-code such as STBB0728K9, enter it as STBB0728 without the filling-code 'K9'.

Not Finding What You Are Looking For?

In some cases, a COA may not be available online. If your search was unable to find the COA you can request one.

Request COA

Customers Also Viewed

Slide 1 of 9

1 of 9

Engineering specific chemical modification sites into a collagen-like protein from Streptococcus pyogenes.
Stoichevska V, et al.
Journal of Biomedical Materials Research Part A (2016)

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service