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764612

Sigma-Aldrich

Poly(D,L-lactide)

average Mn 5,000, PDI ≤1.1

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Synonym(s):
PDLA, PLA, polyDL-lactide

form

solid

Quality Level

mol wt

average Mn 5,000

degradation timeframe

<6 months

mp

264-270 °C

PDI

≤1.1

storage temp.

2-8°C

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This Item
764620767344765112
Poly(D,L-lactide) average Mn 5,000, PDI &#8804;1.1

Sigma-Aldrich

764612

Poly(D,L-lactide)

Poly(D,L-lactide) average Mn 10,000, PDI &#8804;1.2

Sigma-Aldrich

764620

Poly(D,L-lactide)

Poly(D,L-lactide) average Mn 20,000 (NMR), PDI &#8804;1.3

Sigma-Aldrich

767344

Poly(D,L-lactide)

Poly(L-lactide) average Mn 10,000, PDI &#8804;1.1

Sigma-Aldrich

765112

Poly(L-lactide)

mp

264-270 °C

mp

287-293 °C

mp

320-350 °C

mp

-

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

mol wt

average Mn 5,000

mol wt

average Mn 10,000

mol wt

average Mn 20,000 (NMR)

mol wt

average Mn 10,000

degradation timeframe

<6 months

degradation timeframe

<6 months

degradation timeframe

<6 months

degradation timeframe

>3 years

PDI

≤1.1

PDI

≤1.2

PDI

≤1.3

PDI

≤1.1

Application

Used in Drug Delivery including coating nanoparticles. Can be end-group functionalizated or used as a macroinitiator/block precursor.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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25G
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1000309185

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Poly(L-lactide) average Mn 40,000

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Poly(L-lactide) viscosity ~1.0&#160;dL/g, 0.1&#160;% (w/v) in chloroform(25&#160;°C)

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Poly(L-lactide)

Poly(D-lactide) inherent viscosity ~1.2 dl/g

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Poly(D-lactide)

Wolf, Florian F.; et al.
Macromolecules, 42, 5622-5628 (2009)
Zhang, Wen-Bin; et al.
Macromolecules, 44, 2589-2596 (2011)
Preparation of Protein-Loaded Poly(L-Lactide) Microspheres by Solution-Enhanced Dispersion by Supercritical CO2
Chen A Z, et al.
Journal of Biomimetics, Biomaterials, and Tissue Engineering, 11, 93-100 (2011)

Articles

Local delivery of bioactive molecules using an implantable device can decrease the amount of drug dose required as well as non-target site toxicities compared to oral or systemic drug administration.

The world of commercial biomaterials has stagnated over the past 30 years as few materials have successfully transitioned from the bench to clinical use. Synthetic aliphatic polyesters have continued to dominate the field of resorbable biomaterials due to their long history and track record of approval with the U.S. Food and Drug Administration (FDA).

Aliphatic polyesters such as polylactide, poly(lactide-co-glycolide) and polycaprolactone, as well as their copolymers, represent a diverse family of synthetic biodegradable polymers that have been widely explored for medical uses and are commercially available.

Wide range of functional polymers for biomedical applications have been synthesized and structurally characterized. Several classes of polymers including biodegradable polymers, hydrophilic & amphiphilic polymers, and stimuli responsive polymers have been prepared using controlled and directed functionalization via "living" polymerization such as RAFT, ionic and ring opening polymerization. Selected polymers have been studied for their structure-properties relationship. "

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