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912034

Sigma-Aldrich

Trimethyl chitosan

high molecular weight, degree of quaternization 30-70%

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Synonym(s):
N,N,N-Trimethyl chitosan, Chitosan trimethyl, Mucoadhesive polymers, TMC Chitosan
Linear Formula:
(C9H18ClNO4)n
CAS Number:
52349-26-5

Quality Level

100

form

powder

color

light yellow to light brown

storage temp.

2-8°C

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This Item
912123912700419419
Trimethyl chitosan high molecular weight, degree of quaternization 30-70%

Sigma-Aldrich

912034

Trimethyl chitosan

Trimethyl chitosan medium molecular weight, degree of quaternization: 40- 60%

Sigma-Aldrich

912123

Trimethyl chitosan

Trimethyl chitosan low molecular weight, degree of quaternization >50%

Sigma-Aldrich

912700

Trimethyl chitosan

Chitosan high molecular weight

Sigma-Aldrich

419419

Chitosan

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

-

color

light yellow to light brown

color

light yellow to light brown

color

light yellow to light brown

color

-

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

Application

Chitosan offers remarkable biological properties, it has been widely used in drug delivery and tissue engineering applications. Chitosan has good mucoadhesive properties due to its positive charge, which increases the adhesion to mucosa and facilitates drug penetration. Also, chitosan possesses hemostatic properties, which makes it a good candidate for wound dressing applications.

The quaternization of the primary amine increases the water solubility of chitosan and keeps chitosan soluble over a wide pH range. Among all the quaternized chitosans, N, N, N-trimethyl chitosan chloride (TMC) is the most widely applied in biomedical applications.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Preparation and Characterization of Particles from Chitosan with Different Molecular Weights and Their Trimethyl Chitosan Derivatives for Nasal Immunization.
Boonyo W, et al.
Journal of Metals, Materials and Minerals, 18(2), 59-65 (2008)
Rajesh Kumar Kainthan et al.
Biomaterials, 27(31), 5377-5390 (2006-07-21)
A novel class of hyperbranched polymers based on polyglycerol (PG) and poly(ethylene glycol) (PEG) are synthesized by multibranching anionic ring opening polymerization. Multivalent cationic sites are added to these polymers by a post-amination and quarternization reactions. Blood compatibility studies using
Chitosan and Chitosan Derivatives in Drug Delivery and Tissue Engineering.
Riva R, et al.
Advances in Polymer Science, 244, 19-44 (2011)
Rajesh Kumar Kainthan et al.
Biomacromolecules, 9(3), 886-895 (2008-02-06)
This paper discusses the binding and release properties of hydrophobically modified hyperbranched polyglycerol-polyethylene glycol copolymers that were originally developed as human serum albumin (HSA) substitutes. Their unimolecular micellar nature in aqueous solution has been proven by size measurements and other
Preparation and NMR characterization of highly substituted IV-trimethyl chitosan chloride.
Sieval A B, et al.
Carbohydrate Polymers, 36, 157-165 (1998)
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