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933899

Sigma-Aldrich

N-(2-Hydroxy) propyl-3-trimethylammonium chitosan chloride

degree of quaternization 50%

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Synonym(s):
Chioisan, HTCC, Quaternized Chitosan, Solube chitosan, TMC, Trimethyl chitoan
Linear Formula:
(C12H25N2O5Cl)n(C8H13NO5)m

description

NMR: Conforms to structure

Quality Level

form

(solid, chunks or fiber)

color

white to off-white

storage temp.

2-8°C

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This Item
SMB00279912123912034
Trimethyl chitosan medium molecular weight, degree of quaternization: 40- 60%

Sigma-Aldrich

912123

Trimethyl chitosan

Trimethyl chitosan high molecular weight, degree of quaternization 30-70%

Sigma-Aldrich

912034

Trimethyl chitosan

color

white to off-white

color

white to off-white

color

light yellow to light brown

color

light yellow to light brown

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

Quality Level

100

Quality Level

200

Quality Level

100

Quality Level

100

description

NMR: Conforms to structure

description

-

description

-

description

-

General description

Chitosan offers remarkable biological properties; it has been widely used in drug delivery and tissue engineering applications. Chitosan has good mucoadhesive properties due to its positive charge, which increases the adhesion to mucosa and facilitates drug penetration. Also, chitosan possesses hemostatic properties, which makes it a good candidate for wound dressing applications.

The quaternization of the primary amine increases the water solubility of chitosan and keeps chitosan soluble over a wide pH range. Cationically modified chitosan such as N-(2-Hydroxy)propyl-3-trimethyl ammonium chitosan chloride (HTCC) also imparts excellent antibacterial activity and immuno-enhancing characteristics. HTCC also used in gene delivery applications

Application

Small molecule and nucleic acid delivery
Tissue engineering
Antibacterial coatings

Features and Benefits

Water soluble
Cationically modified
Naturally derived and biocompatible

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Microbiocidal activity of chitosan-N-2-hydroxypropyl trimethyl ammonium chloride
Chi W, et al.
Journal of Applied Polymer Science, 103, 3851-3856 (2007)
Bo Xiao et al.
Colloids and surfaces. B, Biointerfaces, 91, 168-174 (2011-11-23)
A series of N-(2-hydroxy)propyl-3-trimethyl ammonium chitosan chloride (HTCC) samples with various degrees of quaternization ranging from 12.4 to 43.7% was synthesized. The structures and properties of HTCC were investigated by FT-IR, (1)H NMR, conductometric titration and XRD analysis. It was
Hamid Hamedi et al.
Carbohydrate polymers, 199, 445-460 (2018-08-26)
Advanced development of chitosan hydrogels has led to new drug delivery systems that can release their active ingredients in response to environmental stimuli. This review considers more recent investigation of chitosan hydrogel preparations and the application of these preparations for
Kai Zhao et al.
Vaccines, 9(9) (2021-09-29)
Porcine parvovirus (PPV) is the most important infectious agent causing infertility in pigs, which can be prevented by routine vaccination. Successful vaccination depends on the association with potent adjuvants that can enhance the immunogenicity of antigen and activate the immune

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