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923834

Sigma-Aldrich

Chitosan-mPEG 1k

25-60% PEGylation, medium MW

Synonym(s):
Medium MW, PEGylated Chitosan
Linear Formula:
(C8H13NO5)p((C2H4O)nC10H17NO6)m

Quality Level

form

solid (powder or chunk(s) or fiber)

color

white to off-white

storage temp.

2-8°C

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This Item
920444920819JKA3115
Chitosan-mPEG 1k 25-60% PEGylation, medium MW

Sigma-Aldrich

923834

Chitosan-mPEG 1k

mPEG20K-MAL average Mn 20,000

Sigma-Aldrich

JKA3115

mPEG20K-MAL

color

white to off-white

color

white to off-white

color

white to off-white

color

-

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

-

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

-

Application

  • Chitosan has in the last decades been widely used in a variety of applications, both industrially and pharmaceutically.
  • Its positive charges under slightly acidic conditions allow it to form complexes or nanoparticles.
  • During the delivery process, the stable compact structure of the complex, with cationic chitosan chains as the outershell and the anionic genes/drugs as the core, efficiently protects genes/drugs from the ″sweeping effect″ of mucociliary clearance and degradation by enzymes.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Li Xiang et al.
Physical chemistry chemical physics : PCCP, 21(37), 20571-20581 (2019-08-01)
PEGylation can modify the physicochemical properties of native chitosan and improves its water solubility. PEGylated chitosan has been widely used as a gene/drug delivery vector by forming a polyelectrolyte complex (PEC) in biomedical engineering. The molecular interactions of PEGylated chitosan
H Ragelle et al.
Journal of controlled release : official journal of the Controlled Release Society, 176, 54-63 (2014-01-07)
This study aims at developing chitosan-based nanoparticles suitable for an intravenous administration of small interfering RNA (siRNA) able to achieve (i) high gene silencing without cytotoxicity and (ii) stability in biological media including blood. Therefore, the influence of chitosan/tripolyphosphate ratio
Peggy Chan et al.
Biomaterials, 28(3), 540-549 (2006-09-27)
Poor water solubility and low transfection efficiency of chitosan are major drawbacks for its use as a gene delivery carrier. PEGylation can increase its solubility, and folate conjugation may improve gene transfection efficiency due to promoted uptake of folate receptor-bearing
PEGylated chitosan derivatives:Synthesis, characterizations and pharmaceutical applications
Casettarietal L, et al.
Progress in Polymer Science, 37, 659-685 (2012)

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