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913375

Sigma-Aldrich

Branched polyethylenimine solution

2mg/mL aqueous solution, suitable for biomedical research

Synonym(s):
PEI solution
Linear Formula:
H(NHCH2CH2)mNH2
CAS Number:

Quality Level

form

liquid

concentration

2 mg/mL

color

colorless to pale yellow

storage temp.

2-8°C

InChI

1S/C2H5N/c1-2-3-1/h3H,1-2H2

InChI key

NOWKCMXCCJGMRR-UHFFFAOYSA-N

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This Item
764604900743900926
Branched PEI-g-PEG PEG Mn 5,000

Sigma-Aldrich

900743

Branched PEI-g-PEG

Branched PEI-g-PEG PEG Mn 550

Sigma-Aldrich

900926

Branched PEI-g-PEG

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

concentration

2 mg/mL

concentration

-

concentration

-

concentration

-

color

colorless to pale yellow

color

-

color

-

color

-

Quality Level

100

Quality Level

-

Quality Level

100

Quality Level

100

Application

High molecular weight branched PEI is commonly used in gene delivery due to its high transfection efficiency in a broad range of cells. Branched PEI has been used to successfully deliver genetic material both in vitro and in vivo, while maintaining low cytotoxicity with DNA complexation.

Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1


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W T Godbey et al.
Journal of biomedical materials research, 45(3), 268-275 (1999-07-09)
Poly(ethylenimine) (PEI) samples of various molecular weights and pHs were used to transfect endothelial cells to achieve levels of gene expression for comparison. PEIs with nominal molecular weights of 600, 1200, 1800, 10,000, and 70,000 Da were examined at pHs
O Boussif et al.
Proceedings of the National Academy of Sciences of the United States of America, 92(16), 7297-7301 (1995-08-01)
Several polycations possessing substantial buffering capacity below physiological pH, such as lipopolyamines and polyamidoamine polymers, are efficient transfection agents per se--i.e., without the addition of cell targeting or membrane-disruption agents. This observation led us to test the cationic polymer polyethylenimine

Articles

Recent Progress on Nonviral Delivery Carriers for CRISPR/Cas9 Systems

The CRISPR/Cas9 system has recently emerged as a highly specific, efficient, and versatile gene editing technology that can be utilized to build disease models and correct diseased genes. Safe and effective delivery vectors for the CRISPR/Cas9 system are in critical need to enable clinical development and future applications of CRISPR/Cas9 systems. Professor Yang Liu summarizes recent progress in nonviral nanoparticle approaches for CRISPR/Cas9 delivery.

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