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920444

Sigma-Aldrich

mPEG functionalized gelatin

50% PEGylation, PEG average Mn 1k, gel strength 300 g Bloom

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Synonym(s):
PEGylated Gelatin
Linear Formula:
(C32H50N9O12-)m(CH2CH2O)n

Quality Level

form

(solid or chunk(s) or fiber)

mol wt

PEG average Mn 1k

color

white to off-white

storage temp.

2-8°C

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This Item
924504900628900741
Sigma-Aldrich

Sigma-Aldrich

924504

Gelatin Type A

Gelatin methacryloyl gel strength 90-110 g Bloom, degree of substitution 60%

Sigma-Aldrich

900628

Gelatin methacryloyl

Gelatin methacryloyl gel strength 170-195 g Bloom, degree of substitution: 60%

Sigma-Aldrich

900741

Gelatin methacryloyl

color

white to off-white

color

white to pale yellow

color

-

color

-

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

storage temp.

2-8°C

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

mol wt

PEG average Mn 1k

mol wt

-

mol wt

-

mol wt

-

Application

mPEG functionalized gelatin is Type A gelatin grafted with PEG that can be used in drug delivery research. Gelatin is a denatured protein that is obtained by hydrolysis of animal collagen. Its biodegradability, biocompatibility, chemical modification potential and cross-linking possibility make gelatin-based nanoparticles (GNPs) a promising carrier system for drug delivery applications. mPEG functionalization has several advantages − prolonged circulation in the body, decreased degradation by metabolic enzymes, and reduction or elimination of protein immunogencity.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Modified gelatin nanoparticles for gene delivery.
Wettig S D, et al.
Int. J. Pharmacol., 554, 224-234 (2019)
A novel smart PEGylated gelatin nanoparticle for co-delivery of doxorubicin and betanin: A strategy for enhancing the therapeutic efficacy of chemotherapy.
Ghorbani M, et al.
Materials Science and Engineering, C, 97, 833-841 (2019)
Sajed Amjadi et al.
Materials science & engineering. C, Materials for biological applications, 97, 833-841 (2019-01-27)
Betanin (BET) can reduce the side effects of potent anticancer drugs e.g. doxorubicin (DOX) on the normal tissues in co-administration with them because of the synergistic therapeutic effect and consequently the reduced required amount of anticancer agents. Despite interest in
Ahmed O Elzoghby
Journal of controlled release : official journal of the Controlled Release Society, 172(3), 1075-1091 (2013-10-08)
Gelatin is one of the most versatile natural biopolymers widely used in pharmaceutical industries due to its biocompatibility, biodegradability, low cost and numerous available active groups for attaching targeting molecules. These advantages led to its application in the synthesis of

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