MilliporeSigma
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926019

Sigma-Aldrich

TissueFab® bioink kit

(Gel)ma Fibronection -Vis/405 nm, low endotoxin

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form

viscous liquid (gel)

size

10 mL

impurities

<5 cfu/mL Bioburden
<50 EU/mL Endotoxin

color

pale yellow to colorless

pH

6.5-7.5

viscosity

3-30 cP

application(s)

3D bioprinting

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form

viscous liquid (gel)

form

viscous liquid (gel)

form

(Solid chunks, fibers or powder)

form

viscous liquid (gel)

size

10 mL

size

10 mL

size

-

size

-

impurities

<5 cfu/mL Bioburden

impurities

<5 cfu/mL Bioburden, <50 EU/mL Endotoxin

impurities

<10 CFU/g Bioburden (Fungal) , <10 CFU/g Bioburden (Total Aerobic), <125 EU/g Endotoxin

impurities

<5 CFU/g Bioberden: Aerobic, <5 CFU/g Bioberden: Fungal, <50 EU/mL Endotoxin

color

pale yellow to colorless

color

pale yellow to colorless

color

, Pale white to colorless

color

pale yellow to colorless

pH

6.5-7.5

pH

6.5-7.5

pH

-

pH

6.5-7.5

viscosity

3-30 cP

viscosity

3-30 cP

viscosity

-

viscosity

3-30 cP

General description

Gelatin methacryloyl (GelMA) is a polymerizable hydrogel material derived from natural extracellular matrix (ECM) components. Due to its low cost, abundance, and retention of natural cell binding motifs, gelatin has become a highly sought material for tissue engineering applications. Fibronectin is a multifunctional glycoprotein which exists as two major isoforms, one soluble and one insoluble form. The former is present in plasma, whereas the insoluble form resides in tissues and extracellular matrix (ECM) of cartilage. Fibronectin is known to contain integrin binding sequences which facilitate cell-matrix interactions.

Application

The addition of photocrosslinkable methacrylamide functional groups in GelMA allows the synthesis of biocompatible, biodegradable, and non-immunogenic hydrogels that are stable in biologically relevant conditions and promote cell adhesion, spreading, and proliferation. Gelatin methacrylate based bioinks have been used to bioprint osteogenic [1], chondrogenic [2-3], hepatic [4-6], adipogenic [7], vasculogenic [8], epithelial [6], endothelial [9-10], cardiac valve [11], skin [12], tumor [10] and other tissues and constructs. Fibronectin plays an essential role in multiple biological functions such as, angiogenesis, cell migration and differentiation and wound healing. Fibronectin has been used in tissue engineering applications for wound healing and angiogenesis[13], bone repair [14] and studying mechanotransduction[15].

Features and Benefits

In addition to fast gelation, the methacrylamide functional group can also be used to control the hydrogel physical parameters such as pore size, degradation rate, and swell ratio. Temporal and spatial control of the crosslinking reaction can be obtained by adjusting the degree of functionalization and polymerization conditions, allowing for the fabrication of hydrogels with unique patterns, 3D structures, and morphologies.

Legal Information

TISSUEFAB is a registered trademark of Sigma-Aldrich Co. LLC

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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25G
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