I-034

Human Insulin solution

100 μg/mL in PBS, pH 7.2, certified reference material, ampule of 100 μL, Cerilliant^®

• Empirical Formula (Hill Notation): C₂₅₇H₃₈₃N₆₅O₇₇S₆
• CAS Number: 11061-68-0
• Molecular Weight: 5807.57
• UNSPSC Code: 41116107
• NACRES: NA.24

Properties

• grade: certified reference material
• Quality Level: 300
• form: liquid
• feature: Snap-N-Spike^®/Snap-N-Shoot^®
• packaging: ampule of 100 μL
• manufacturer/tradename: Cerilliant^®
• concentration: 100 μg/mL in PBS, pH 7.2
• technique(s): liquid chromatography (LC): suitable
• application(s): clinical testing
• format: single component solution
• storage temp.: −20°C
• InChI key: PBGKTOXHQIOBKM-FHFVDXKLSA-N

Description

General description

Human insulin is a peptide hormone, composed of 51 amino acids, produced by beta cells of the pancreatic islets. Insulin regulates the metabolism of carbohydrates, fats and protein by promoting the absorption of, especially glucose from the blood into liver, fat and skeletal muscle cells. Insulin levels are routinely measured to evaluate insulin production; diagnose insulin-producing tumors; determine hypoglycemia or to identify insulin resistance. This certified Snap-N-Spike^® solution of the fully-intact human insulin protein is suitable for use as starting material in calibrators and controls in LC-MS/MS insulin testing methods.

The Recombinant Human Insulin in phosphate buffered saline (PBS), pH 7.2 (solution) is a standard that fulfills the criteria set by ISO for a certified reference material and a primary standard. It is traceable to the SI and higher order standards through a continuous series of comparisons.

Application

Human Insulin solution is suitable for the in vitro identification, calibration, and quantification of the analyte(s) in analytical and R&D applications.

Features and Benefits

• The active insulin content is determined through quantitative amino acid analysis (AAA) and chromatographic purity.
• Each raw material used in the standard has undergone identification and thorough characterization using multiple analytical techniques.
• A Mass Balance Purity Factor is assigned to each raw material.
• The standard is prepared using balances that are fully qualified and calibrated to meet ISO 17025 requirements.
• The standard is prepared and certified under the ISO 17034, ISO/IEC 17025, ISO 9001, and ISO 13485 standards.

Preparation Note

• Thaw the product at refrigerator or room temperature.
• Mix well before use.
• Once thawed, do not refreeze the product.
• Use established good laboratory practices to quantitatively transfer the desired volume and spike the product into a matrix or dilute it to the desired concentration.

Other Notes

This product′s purpose is for testing. THIS PRODUCT IS NOT INTENDED FOR HUMAN OR THERAPEUTIC USE. Please refer to the safety data sheet for specific details regarding any possible hazards and necessary precautions.

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk_germany: nwg
• flash_point_f: Not applicable
• flash_point_c: Not applicable