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Key Documents

04-004

Sigma-Aldrich

Anti-SOCS3 Antibody, clone 1B2

clone 1B2, Upstate®, from mouse

Synonym(s):

suppressor of cytokine signaling 3, ATOD4, CIS3, Cish3, MGC71791, SOCS-3, SSI-3, SSI3

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

mouse

Quality Level

100

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

1B2, monoclonal

species reactivity

mouse, human

manufacturer/tradename

Upstate®

technique(s)

western blot: suitable

isotype

IgG1

NCBI accession no.

NM_003955.3

UniProt accession no.

O14543

shipped in

dry ice

target post-translational modification

unmodified

Gene Information

human ... SOCS3(9021)

Specificity

Recognizes SOCS3.

Immunogen

mouse SOCS3 recombinant GST fusion protein encompassing amino acids 2-44.

Application

Research Sub Category
Neuroregenerative Medicine

Developmental Neuroscience
This Anti-SOCS3 Antibody, clone 1B2 is validated for use in WB for the detection of SOCS3.

Quality

Routinely evaluated by immunoblot.

Target description

25 kDa

Physical form

Format: Purified
Protein G Purified mouse monoclonal IgG in a solution of 50% glycerol, 0.02 M Phosphate buffer, pH 7.6, 0.25 M NaCl, 0.1% sodium azide as a preservative.

Other Notes

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class

12 - Non Combustible Liquids

wgk_germany

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Sam Ansari et al.
Scientific data, 3, 150077-150077 (2016-01-06)
Smoking of combustible cigarettes has a major impact on human health. Using a systems toxicology approach in a model of chronic obstructive pulmonary disease (C57BL/6 mice), we assessed the health consequences in mice of an aerosol derived from a prototype
Evdokia Dimitriadis et al.
Endocrinology, 147(8), 3809-3817 (2006-05-20)
The differentiation of endometrial stromal cells into decidual cells (decidualization) is critical for embryo implantation, but the mechanisms remain poorly defined. Numerous paracrine agents including IL-11 promote human endometrial stromal cell (HESC) decidualization. IL-11 signaling is transduced by the signal
Daniel J Ham et al.
American journal of physiology. Endocrinology and metabolism, 310(11), E970-E981 (2016-04-21)
Amino acids, especially leucine, potently stimulate protein synthesis and reduce protein breakdown in healthy skeletal muscle and as a result have received considerable attention as potential treatments for muscle wasting. However, the normal anabolic response to amino acids is impaired
Transcriptional profiling and targeted proteomics reveals common molecular changes associated with cigarette smoke-induced lung emphysema development in five susceptible mouse strains.
Cabanski, M; Fields, B; Boue, S; Boukharov, N; DeLeon, H; Dror, N; Geertz, M; Guedj et al.
Inflammation Research null
Kate D Sutherland et al.
Oncogene, 23(46), 7726-7733 (2004-09-14)
Suppressor of cytokine signaling (SOCS) proteins have emerged as critical attenuators of cytokine-mediated processes, suggesting a role in the suppression of tumorigenesis. In the ovary and mammary gland, cytokines such as prolactin and IL-6 are important regulators of growth and
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