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Chromolith® RP-18 endcapped

L × I.D. 100 mm x 25 mm Prep column

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Chromolith® Prep RP-18 endcapped 100-25 column


PEEK column

Quality Level


suitable for USP L1

product line





1 ea of

extent of labeling

18% Carbon loading


100 bar pressure
45 °C max. temp.


HPLC: suitable
LC/MS: suitable (Prep LC)
UHPLC-MS: suitable
UHPLC: suitable

column L × I.D.

10 cm × 2 mm


monolithic silica

matrix active group

C18 bonding phase

pore size

12 nm mesoporosity
3 μm macroporosity

operating pH range


separation technique

reversed phase

storage temp.

no temp limit

Related Categories

General description

Preparative HPLC involves much higher sample loading volumes than analytical chromatography. Consequently, greater sample throughput and separation speed are essential for optimal productivity. These criteria are best fulfilled by Chromolith® Prep RP-18 endcapped columns. The combination of macro and mesopores maximizes separation efficiency and flow rate, while minimizing resistance.

The revolutionary, monolithic silica with its unique combination of macropores and mesopores enables:
—Rapid separations at very low column back-pressure
—High matrix tolerance, allowing time and cost savings with simplified workflows
—Cost savings due to extended column lifetimes

Learn more:
Brochure: Race through your Separations on Any System. Chromolith® Monolithic Silica HPLC Columns

Analysis Note

Pressure: ≤ 20 bar
Theoretical Plates (N/m) (Anthracene): ≥ 40000
Capacity factor (Anthracene): 3.0 - 4.5
Tailing (USP): 0.8 - 1.4 %
separation factor (anthracene/progesterone): 1.9 - 2.5

Legal Information

Chromolith is a registered trademark of Merck KGaA, Darmstadt, Germany

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