176870

Angiotensinogen, Human Plasma

Native angiotensinogen from human plasma that is cleaved by renin to generate angiotensin I. It is a part of the renin-angiotensin system that regulates blood pressure and fluid balance.

• Synonym(s): Angiotensinogen, Human Plasma, AGT, Hypertensinogen, Serpin A8
• CAS Number: 11002-13-4
• MDL number: MFCD00151759
• UNSPSC Code: 12352202
• NACRES: NA.77

Properties

• Quality Level: 100
• assay: ≥95% (SDS-PAGE)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze
• technique(s): cell based assay: suitable
• solubility: water: soluble
• NCBI accession no.: NM_001384479
• UniProt accession no.: P01019
• shipped in: ambient
• storage temp.: −20°C
• Gene Information: human ... AGT(183)

Description

General description

Research area: CELL SIGNALING

Native angiotensinogen from human plasma is an α2-globulin present in plasma at about 7 mg/100 ml.

Angiotensinogen serves as a precursor for the production of angiotensin. In humans, angiotensinogen is composed of 485 amino acids. It is primarily synthesized and continuously secreted by the liver.

Application

Angiotensinogen has been used for the detection and analysis of the complexes formed between angiotensinogen and proform of eosinophil major basic protein (ProMBP) in both serum and amniotic fluid during pregnancy through ELISA.

Biochem/physiol Actions

Angiotensinogen acts as a precursor molecule in the renin-angiotensin-aldosterone system (RAAS) pathway. It is a part of the renin-angiotensin system that regulates blood pressure and fluid balance. Moreover, overactivation of the RAAS system has been associated with the development of several types of cancer, cardiovascular and renal diseases. Furthermore, in certain cancers angiotensin II has been shown to promote cancer metastasis.

Warning

Toxicity: Standard Handling (A)

Physical form

Lyophilized from 50 mM sodium phosphate, 150 mM NaCl, pH 7.0.

Preparation Note

Please refer to vial label for lot-specific concentration prior to lyophilization.

Prepared from plasma that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Jeunemaitre, X., et al. 1992. Cell71, 169.
Tewksbury, D.A. 1983. Fed. Proc.42, 2724.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3