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196418

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BAPTA, Tetrasodium Salt

Ca2+ chelator exhibiting a 105-fold greater affinity for Ca2+ .

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Synonym(s):
BAPTA, Tetrasodium Salt, 1,2- bis( o-Aminophenoxy)ethane-N,N,Nʹ,Nʹ-tetraacetic Acid, 4Na, 1,2-bis(o-Aminophenoxy)ethane-N,N,Nʹ,Nʹ-tetraacetic Acid, 4Na
Empirical Formula (Hill Notation):
C22H20N2O10 · 4Na
CAS Number:
Molecular Weight:
564.36
MDL number:

Quality Level

form

solid

reaction suitability

reagent type: chelator

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated (hygroscopic)
protect from light

color

off-white

solubility

water: 10 mg/mL

shipped in

ambient

storage temp.

−20°C

InChI

1S/C22H24N2O10.4Na/c25-19(26)11-23(12-20(27)28)15-5-1-3-7-17(15)33-9-10-34-18-8-4-2-6-16(18)24(13-21(29)30)14-22(31)32;;;;/h1-8H,9-14H2,(H,25,26)(H,27,28)(H,29,30)(H,31,32);;;;/q;4*+1/p-4

InChI key

ZWSMLJACYSGFKD-UHFFFAOYSA-J

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This Item
A107614513196419
BAPTA, Tetrasodium Salt Ca2+ chelator exhibiting a 105-fold greater affinity for Ca2+ .

196418

BAPTA, Tetrasodium Salt

BAPTA-AM ≥95% (HPLC)

A1076

BAPTA-AM

BAPTA/AM Membrane-permeable form of BAPTA.

196419

BAPTA/AM

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

solubility

water: 10 mg/mL

solubility

-

solubility

H2O: 10 mg/mL, clear, faintly yellow

solubility

DMSO: 10 mg/mL

form

solid

form

powder

form

powder

form

solid

reaction suitability

reagent type: chelator

reaction suitability

-

reaction suitability

-

reaction suitability

reagent type: chelator

manufacturer/tradename

Calbiochem®

manufacturer/tradename

-

manufacturer/tradename

-

manufacturer/tradename

Calbiochem®

General description

Ca2+-chelator exhibiting a 105-fold greater affinity for Ca2+ (110 nM) than for Mg2+. After BAPTA complexes with Ca2+, the UV spectrum shifts from 254 to 279 nm at pH >6.0. Useful for spectrophotometric monitoring of extracellular Ca2+ levels, especially transient phenomena, because of its insensitivity to pH. Has been used for the measurement and control of Ca2+ levels in eggs, chromaffin cells, muscle cells, retinal cells, and pancreatic cells. In conjunction with certain formazan dyes, BAPTA can be used in a colorimetric assay for Mg2+. Has neuroprotective effects in vitro against excitotoxic damage and spontaneous recurrent seizures, such as epilepsy.

Warning

Toxicity: Irritant (B)

Reconstitution

Following reconstitution, aliquot, purge with inert gas and freeze (-20°C). To increase stability in solution, store at a high pH (>10). Stock solutions are stable for up to 1 month at -20°C.

Other Notes

DeLorenzo, R.J., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 14482.
Li, L., et al. 1995. J. Cell Physiol. 163, 105.
Tymianski, M., et al. 1994. J. Neurophysiol. 72, 1973.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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