Skip to Content
MilliporeSigma
All Photos(1)

Documents

298711

Sigma-Aldrich

Diethyl Pyrocarbonate

Inhibits ryanodine binding to ryanodine/Ca2+ receptor channel in skeletal muscle in a dose- and time-dependent manner and increases the Ca2+ permeability of SR vesicles.

Sign Into View Organizational & Contract Pricing

Synonym(s):
Diethyl Pyrocarbonate, Diethyl Oxydiformate, DEPC
Empirical Formula (Hill Notation):
C6H10O5
CAS Number:
Molecular Weight:
162.14
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.77

Quality Level

assay

≥97% (titration)

form

liquid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

clear colorless

solubility

chloroform: soluble
ethanol: soluble

shipped in

ambient

storage temp.

2-8°C

InChI

1S/C6H10O5/c1-3-9-5(7)11-6(8)10-4-2/h3-4H2,1-2H3

InChI key

FFYPMLJYZAEMQB-UHFFFAOYSA-N

General description

Inhibits ryanodine binding to ryanodine/Ca2+ receptor channel in skeletal muscle in a dose- and time-dependent manner and increases the Ca2+ permeability of SR vesicles. Useful for specific inactivation of nucleases during isolation of undegraded polynucleotides. Also inhibits platelet-activating factor acetyl hydrolase. Has been used as a probe for the topography of 5.8S rRNA in yeast ribosomes.
Inhibits ryanodine binding to ryanodine/Ca2+ receptor channel in skeletal muscle. Useful for specific inactivation of nucleases during isolation of undegraded polynucleotides. Also inhibits platelet-activating factor acetyl hydrolase. Has been used as a probe for the topography of 5.8S rRNA in yeast ribosomes.

Biochem/physiol Actions

Cell permeable: no
Primary Target
Inhibits ryanodine binding to ryanodine/Ca2+ receptor channel in skeletal muscle
Product does not compete with ATP.
Reversible: no

Warning

Toxicity: Harmful (C)

Other Notes

Shoshan-Barmatz, V., and Weil, S. 1994. Biochem. J. 299, 177.
Blumbers, D.O. 1987. Methods Enzymol. 152, 20.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

Acute Tox. 4 Oral

wgk_germany

WGK 3

flash_point_f

closed cup

flash_point_c

closed cup


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service