298711
Diethyl Pyrocarbonate
Inhibits ryanodine binding to ryanodine/Ca2+ receptor channel in skeletal muscle in a dose- and time-dependent manner and increases the Ca2+ permeability of SR vesicles.
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Synonym(s):
Diethyl Pyrocarbonate, Diethyl Oxydiformate, DEPC
Empirical Formula (Hill Notation):
C6H10O5
Recommended Products
Quality Level
assay
≥97% (titration)
form
liquid
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
protect from light
color
clear colorless
solubility
chloroform: soluble
ethanol: soluble
shipped in
ambient
storage temp.
2-8°C
InChI
1S/C6H10O5/c1-3-9-5(7)11-6(8)10-4-2/h3-4H2,1-2H3
InChI key
FFYPMLJYZAEMQB-UHFFFAOYSA-N
General description
Inhibits ryanodine binding to ryanodine/Ca2+ receptor channel in skeletal muscle in a dose- and time-dependent manner and increases the Ca2+ permeability of SR vesicles. Useful for specific inactivation of nucleases during isolation of undegraded polynucleotides. Also inhibits platelet-activating factor acetyl hydrolase. Has been used as a probe for the topography of 5.8S rRNA in yeast ribosomes.
Inhibits ryanodine binding to ryanodine/Ca2+ receptor channel in skeletal muscle. Useful for specific inactivation of nucleases during isolation of undegraded polynucleotides. Also inhibits platelet-activating factor acetyl hydrolase. Has been used as a probe for the topography of 5.8S rRNA in yeast ribosomes.
Biochem/physiol Actions
Cell permeable: no
Primary Target
Inhibits ryanodine binding to ryanodine/Ca2+ receptor channel in skeletal muscle
Inhibits ryanodine binding to ryanodine/Ca2+ receptor channel in skeletal muscle
Product does not compete with ATP.
Reversible: no
Warning
Toxicity: Harmful (C)
Other Notes
Shoshan-Barmatz, V., and Weil, S. 1994. Biochem. J. 299, 177.
Blumbers, D.O. 1987. Methods Enzymol. 152, 20.
Blumbers, D.O. 1987. Methods Enzymol. 152, 20.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
wgk_germany
WGK 3
flash_point_f
closed cup
flash_point_c
closed cup
Certificates of Analysis (COA)
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