Skip to Content
MilliporeSigma
All Photos(1)

Documents

324410

Sigma-Aldrich

Dynasore

≥98% (HPLC), solid, dynamin inhibitor, Calbiochem®

Synonym(s):

Dynamin Inhibitor I, Dynasore, 3-Hydroxynaphthalene-2-carboxylic acid-(3,4-dihydroxybenzylidene)-hydrazide, Sore to Dynamin

Sign Into View Organizational & Contract Pricing


About This Item

Empirical Formula (Hill Notation):
C18H14N2O4
CAS Number:
Molecular Weight:
322.31
UNSPSC Code:
12352200
NACRES:
NA.77

product name

Dynamin Inhibitor I, Dynasore, The Dynamin Inhibitor I, Dynasore, also referenced under CAS 304448-55-3, controls the biological activity of Dynamin. This small molecule/inhibitor is primarily used for Membrane applications.

Quality Level

assay

≥98% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

pale yellow

solubility

DMSO: 16 mg/mL

shipped in

ambient

storage temp.

2-8°C

InChI

1S/C18H14N2O4/c21-15-6-5-11(7-17(15)23)10-19-20-18(24)14-8-12-3-1-2-4-13(12)9-16(14)22/h1-10,21-23H,(H,20,24)/b19-10+

InChI key

SYNDQCRDGGCQRZ-VXLYETTFSA-N

General description

A cell-permeable semicarbazone compound that inhibits the GTPase activity of dynamin1/2 (IC50 ~15 µM) and Drp1, while exhibiting no significant effect against two other small GTPases, MxA and Cdc42. Dynasore has been used to elucidate the roles of dynamin in endocytosis mediated by both clathrin-coated and synaptic vesicles. The inhibitition is noncompetitive with respect to GTP and the inhibitor target site presumably resides in the GTPase domain. Shown to inhibit removal of both wt and ΔF508-CFTR from the plasma membrane.

Packaging

Packaged under inert gas

Warning

Toxicity: Environmental Hazard (N)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Young, A., et al. 2009. Biochem. J., In press.
Nankoe, S.R., and Sever, S. 2006. Trends Cell Biol.16, 607.
Newton, A.J., et al. 2006. Proc. Natl. Acad. Sci. USA103, 17955.
Macia. E., et al. 2006. Dev. Cell10, 839.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Customers Also Viewed

Slide 1 of 3

1 of 3

Cytochalasin D Ready Made Solution, from Zygosporium mansonii, 5 mg/mL in DMSO

Sigma-Aldrich

C2618

Cytochalasin D

Sigma-Aldrich

Sigma-Aldrich

SML1006

EGA

Ji Wu et al.
Blood advances, 7(14), 3382-3394 (2023-04-13)
Cell polarity, the asymmetric distribution of proteins and organelles, is permanently or transiently established in various cell types and plays an important role in many physiological events. epidermal growth factor receptor substrate 15 homology domain-binding protein 1-like 1 (EHBP1L1) is
Jinhong Pan et al.
The Journal of pharmacology and experimental therapeutics (2023-07-14)
The ocular surface comprises the wet mucosal epithelia of the cornea and conjunctiva, the associated glands, and the overlying tear film. Epitheliopathy is the common pathological outcome when the ocular surface is subjected to oxidative stress. Whether different stresses act
Gang Xi et al.
Kidney international reports, 9(2), 451-463 (2024-02-12)
Podocyte slit diaphragms are an important component of the glomerular filtration barrier. Podocyte injury frequently includes defects in slit diaphragms, and various mechanisms for these defects have been described, including altered endocytic trafficking of slit diaphragm proteins or oxidative stress.
Elsa M Reyes-Reyes et al.
Methods in molecular biology (Clifton, N.J.), 2036, 173-186 (2019-08-15)
Oligonucleotides can be designed or evolved to bind to specific DNA, RNA, protein, or small molecule targets and thereby alter the biological function of the target. The therapeutic potential of oligonucleotides targeted to intracellular molecules will depend largely on their
Alba García-Fernández et al.
Pharmaceutics, 14(7) (2022-07-28)
In this article, we report one of the few examples of nanoparticles capable of simultaneously delivering CRISPR-Cas9 gene-editing machinery and releasing drugs for one-shot treatments. Considering the complexity of inflammation in diseases, the synergistic effect of nanoparticles for gene-editing/drug therapy

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service