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344906

Sigma-Aldrich

FURA 2/AM in Solution

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Synonym(s):
FURA 2/AM in Solution
Empirical Formula (Hill Notation):
C44H47N3O24
CAS Number:
Molecular Weight:
1001.85
MDL number:

assay

≥95% (HPLC)

Quality Level

form

liquid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

fluorescence

λex 335 nm (high)
λex 362 nm (low)
λem 505 nm (high)
λem 512 nm (low)

shipped in

ambient

storage temp.

−20°C

InChI

1S/C44H47N3O24/c1-25-7-8-32(46(16-38(53)65-20-60-26(2)48)17-39(54)66-21-61-27(3)49)35(13-25)58-11-12-59-42-31-14-36(43-45-15-37(71-43)44(57)69-24-64-30(6)52)70-34(31)10-9-33(42)47(18-40(55)67-22-62-28(4)50)19-41(56)68-23-63-29(5)51/h7-10,13-15H,11-12,16-24H2,1-6H3

InChI key

UTBYGIDPBQOHNT-UHFFFAOYSA-N

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This Item
A410834490547989
vibrant-m

344906

FURA 2/AM in Solution

vibrant-m

A4108

Aminophenyl fluorescein solution

vibrant-m

344905

FURA 2/AM

vibrant-m

47989

Fura 2-AM

form

liquid

form

liquid

form

solid

form

solid

assay

≥95% (HPLC)

assay

-

assay

≥95% (HPLC)

assay

≥95.0% (HPLC)

shipped in

ambient

shipped in

-

shipped in

ambient

shipped in

-

Quality Level

100

Quality Level

200

Quality Level

100

Quality Level

100

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

−20°C

General description

Cell-permeable ester form of FURA 2 (Cat. No. 344900). The active dye is rapidly released in the cell by cytoplasmic esterases. Fluorescent calcium chelator (Kd = 224 nM) that offers 30X greater fluorescence intensity that QUIN 2 (Cat. No. 551826). This probe has been used as a probe in many cellular systems, including cardiac myocytes, vascular smooth muscle cells, and medullary collecting tubules. Spectral properties in the presence of low calcium concentrations (excitation max.: 362 nm, emission max.: 512 nm) differ from those during high calcium conditions (excitation max.: 335 nm, emission max.: 505 nm).

Biochem/physiol Actions

Cell permeable: no
Product does not compete with ATP.
Reversible: no

Packaging

Packaged under inert gas

Warning

Toxicity: Irritant (B)

Physical form

A 1 mM solution of FURA 2/AM (Cat. No. 344905) in anhydrous DMSO.

Reconstitution

Following initial thaw, aliquot and freeze (-20°C). Store frozen under an inert atmosphere.

Other Notes

Davis, M.J., et al. 1992. Am. J. Physiol. 263, H1292.
Rao, G.H., et al. 1992. Biochem. Med. Metab. Biol.47, 226.
Schwartz, Y., et al. 1992. Endocrinology131, 772.
Ward, C.A., and Moffat, M.P. 1992. J. Mol. Cell. Cardiol.24, 937.
Janconi, M.E., et al. 1990. J. Cell Biol.110, 1555.
Tsien, R.Y. 1980. Biochemistry19, 2396.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

188.6 °F - (Dimethylsulfoxide)

flash_point_c

87 °C - (Dimethylsulfoxide)


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Rolando Carrisoza-Gaytan et al.
JCI insight, 5(8) (2020-04-08)
BK channels are expressed in intercalated cells (ICs) and principal cells (PCs) in the cortical collecting duct (CCD) of the mammalian kidney and have been proposed to be responsible for flow-induced K+ secretion (FIKS) and K+ adaptation. To examine the

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