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Anti-nitro-α/β-Synuclein Antibody, clone nSyn12

clone nSyn12, Upstate®, from mouse

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eCl@ss:
32160702
NACRES:
NA.41

biological source

mouse

Quality Level

antibody form

ascites fluid

antibody product type

primary antibodies

clone

nSyn12, monoclonal

species reactivity

human

manufacturer/tradename

Upstate®

technique(s)

immunohistochemistry: suitable
western blot: suitable

NCBI accession no.

UniProt accession no.

shipped in

dry ice

Gene Information

human ... SNCA(6622)

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This Item
36-00936-01236-012-I
biological source

mouse

biological source

mouse

biological source

mouse

biological source

mouse

clone

nSyn12, monoclonal

clone

Syn207, monoclonal

clone

nSyn14, monoclonal

clone

nSyn14, monoclonal

species reactivity

human

species reactivity

rat, mouse, human

species reactivity

human

species reactivity

human, mouse

shipped in

dry ice

shipped in

dry ice

shipped in

dry ice

shipped in

ambient

Gene Information

human ... SNCA(6622)

Gene Information

human ... SNCB(6620)

Gene Information

human ... SNCA(6622)

Gene Information

human ... SCNA(6622)

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Specificity

α-Synuclein nitrated at Tyr125 and Tyr136
β-Synuclein nitrated at Tyr130

Application

Anti-nitro-α/β-Synuclein Antibody, clone nSyn12 is an antibody against nitro-α/β-Synuclein for use in WB, IH.

Quality

rountinely evaluated on recombinant protein nitrated in vitro

Target description

α-Synuclein, Mr 14.5kDa
β-Synuclein, Mr 17kDa

Physical form

Format: Unpurified

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

10 - Combustible liquids

wgk_germany

WGK 1


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Ashley D Reynolds et al.
Journal of neurochemistry, 104(6), 1504-1525 (2007-11-27)
Microglial neuroinflammatory processes play a primary role in dopaminergic neurodegeneration for Parkinson's disease (PD). This can occur, in part, by modulation of glial function following activation by soluble or insoluble modified alpha-synuclein (alpha-syn), a chief component of Lewy bodies that
B I Giasson et al.
The Journal of biological chemistry, 274(12), 7619-7622 (1999-03-13)
alpha-Synuclein is a soluble presynaptic protein which is pathologically redistributed within intracellular lesions characteristic of several neurodegenerative diseases. Here we demonstrate that wild type and two mutant forms of alpha-synuclein linked to familial Parkinson's disease (Ala30 --> Pro and Ala53
Emilio Fernández-Espejo et al.
Antioxidants (Basel, Switzerland), 10(5) (2021-06-03)
Background. Salivary α-synuclein (aSyn) and its nitrated form, or 3-nitrotyrosine-α-synuclein (3-NT-αSyn), hold promise as biomarkers for idiopathic Parkinson's disease (IPD). Nitrative stress that is characterized by an excess of 3-nitrotyrosine proteins (3-NT-proteins) has been proposed as a pathogenic mechanism in
J M Souza et al.
The Journal of biological chemistry, 275(24), 18344-18349 (2000-04-05)
Intracellular proteinaceous aggregates are hallmarks of many common neurodegenerative disorders, and recent studies have shown that alpha-synuclein is a major component of several pathological intracellular inclusions, including Lewy bodies in Parkinson's disease (PD) and glial cell inclusions in multiple system
Nicole Willems et al.
BMC veterinary research, 12, 10-10 (2016-01-14)
Intervertebral disc (IVD) disease is a common spinal disorder in dogs and degeneration and inflammation are significant components of the pathological cascade. Only limited studies have studied the cytokine and chemokine profiles in IVD degeneration in dogs, and mainly focused

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