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400076-M

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Hypericin

Polycyclic dione that has anti-retroviral activity.

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Synonym(s):
Hypericin, Casein Kinase II Inhibitor XI
Empirical Formula (Hill Notation):
C30H16O8
CAS Number:
Molecular Weight:
504.44
MDL number:

Quality Level

assay

≥98% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

black

solubility

ethanol: 1 mg/mL
methanol: 1 mg/mL
DMSO: 10 mg/mL

storage temp.

2-8°C

InChI

1S/C30H16O8/c1-7-3-9(31)19-23-15(7)16-8(2)4-10(32)20-24(16)28-26-18(12(34)6-14(36)22(26)30(20)38)17-11(33)5-13(35)21(29(19)37)25(17)27(23)28/h3-6,31-36H,1-2H3

InChI key

BTXNYTINYBABQR-UHFFFAOYSA-N

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This Item
56690375680218697
Hypericin Polycyclic dione that has anti-retroviral activity.

400076-M

Hypericin

Hypericin from Hypericum perforatum ~95% (HPLC)

56690

Hypericin from Hypericum perforatum

Hesperadin Hesperadin primarily used in Inhibition.

375680

Hesperadin

Casein Kinase II Inhibitor I The Casein Kinase II Inhibitor I, also referenced under CAS 17374-26-4, controls the biological activity of Casein Kinase II. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

218697

Casein Kinase II Inhibitor I

form

solid

form

-

form

solid

form

solid

Quality Level

100

Quality Level

-

Quality Level

100

Quality Level

100

manufacturer/tradename

Calbiochem®

manufacturer/tradename

-

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

storage temp.

2-8°C

storage temp.

-

storage temp.

−20°C

storage temp.

2-8°C

solubility

ethanol: 1 mg/mL, DMSO: 10 mg/mL, methanol: 1 mg/mL

solubility

1 M NaOH: 10 mg/mL, turbid, dark green

solubility

DMSO: 50 mg/mL

solubility

DMSO: 10 mg/mL

General description

Polycyclic dione that has anti-retroviral activity. Inhibits protein kinase C (IC50 = 3.3 µM). Also known to inhibit the protein tyrosine kinase activities of the insulin receptor (IC50 = 20-29 nM), the epidermal growth factor receptor (IC50 = 35 nM), casein kinase II (IC50 = 6 nM), and MAP kinase (IC50 = 4 nM). Useful probe for PKC due to its bright red fluorescence emission and photostability. Also see Pseudohypericin (Cat. No. 539590).
Polycyclic dione that has anti-retroviral activity. Inhibits protein kinase C (IC50 = 3.3 μM). Also known to inhibit casein kinase II (IC50 = 6 nM), MAP kinase (IC50 = 4 nM), and the protein tyrosine activities of the insulin receptor (IC50 = 20-29 nM) and the epidermal growth factor receptor (IC50 = 35 nM).

Biochem/physiol Actions

Primary Target
PKC
Target IC50: 3.3 µM, 6 nM, 4 nM, 20-29 nM , 35 nM, against protein kinase C, casein kinase II, MAP kinase, the protein tyrosine activities of the insulin receptor, and the epidermal growth factor receptor, respectively

Warning

Toxicity: Harmful (C)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Zhang, W., et al. 1997. Cancer Lett.120, 31.
Agostinis, P., et al. 1995. Biochem. Pharmacol.49, 1615.
Frew, T., et al. 1994. Anticancer Res.14, 2425.
Barnard, D.L., et al. 1992. Antiviral Res.17, 63.
Takahashi, I., et al. 1989. Biochem. Biophys. Res. Commun.165, 1207.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

pictograms

Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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