407294

αA-Interferon, Human, Recombinant, E. coli

• Synonym(s): IFNA2A, IFNA2B, IFNA2C, rhIFN-αA
• UNSPSC Code: 12352202
• NACRES: NA.77

Properties

• assay: ≥95% (SDS-PAGE)
• Quality Level: 100
• form: liquid
• specific activity: ≥2.8 x 10⁸ units/mg protein; ≥5 x 10⁶ units/mL
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; avoid repeated freeze/thaw cycles
• technique(s): cell based assay: suitable
• NCBI accession no.: NM_000605.4
• UniProt accession no.: P01563
• shipped in: wet ice
• storage temp.: −70°C
• Gene Information: human ... IFNA1(3340)

Description

General description

Note: 1 MU = 1,000,000 units.

Recombinant, human αA-interferon expressed in E. coli. Antiviral, anti-neoplastic agent. αA-Interferon exhibits therapeutic potential in chronic viral hepatitis, polycythemia vera, and various malignancies. It enhances natural killer cell activity, suppresses bone marrow function, and induces apoptotic cell death in non-melanoma skin cancer.

Recombinant, human αA-interferon expressed in E. coli. Antiviral, anti-neoplastic agent. αA-Interferon exhibits therapeutic potential with chronic viral hepatitis, polycythemia vera, and various malignancies. It enhances natural killer cell activity, suppresses bone marrow function, and induces apoptotic cell death in non-melanoma skin cancer. NOTE: 1MU = 1,000,000 units.

Warning

Toxicity: Standard Handling (A)

Unit Definition

One unit of interferon per ml of medium will cause a 50% inhibition of VSV-induced cytopathic effect on bovine MDBK cells. Units are determined with respect to the NIH international reference standard for human αA-IFN. Dilute in aqueous buffer containing at least 0.1% BSA or HSA.

Physical form

In PBS containing 0.1% BSA.

Preparation Note

Dilute only in buffers containing protein such as 0.1% BSA.

Reconstitution

Following initial thaw, aliquot and freeze (-70°C).

Other Notes

Fujishima, H., et al. 1998. Int. J. Cancer 76, 423.
Haria, M., and Benfield, P. 1995. Drugs 50, 873.
Familletti, P.C., et al. 1981. Methods Enzymol. 78, 387.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 1
• flash_point_f: Not applicable
• flash_point_c: Not applicable