420307
Kallikrein, Human Plasma
Native Kallikrein from human plasma. A serine protease that releases bradykinin from kininogen. Present in the plasma as an inactive precursor, prokallikrein.
Synonym(s):
Kallikrein, Human Plasma, Kininogenin, Kininogenase
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About This Item
CAS Number:
MDL number:
UNSPSC Code:
12352202
NACRES:
NA.77
Pricing and availability is not currently available.
Recommended Products
biological source
human plasma
Quality Level
description
Merck USA index - 14, 5279
assay
≥95% (SDS-PAGE)
form
liquid
specific activity
≥15 units/mg protein
manufacturer/tradename
Calbiochem®
storage condition
OK to freeze
avoid repeated freeze/thaw cycles
storage temp.
−20°C
General description
Native Kallikrein from human plasma. A serine protease that releases bradykinin from kininogen. Present in the plasma as an inactive precursor, prokallikrein.
Packaging
Please refer to vial label for lot-specific concentration.
Warning
Toxicity: Harmful (C)
Unit Definition
One unit is defined as the amount of enzyme that will hydrolyze 1.0 µmol D-Pro-Phe-Arg-pNA per min at 25°C, pH 8.0.
Physical form
In NaCl and Tris-HCl buffer.
Preparation Note
Prepared from plasma that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
Reconstitution
Following initial thaw, aliquot and freeze (-20°C).
Other Notes
Pu, X., et al. 1994. Biochim. Biophys. Acta 1208, 338.
Nagase, H. and Barrett, A.J. 1981. Biochem. J.193, 187.
Nagase, H. and Barrett, A.J. 1981. Biochem. J.193, 187.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.
Storage Class
12 - Non Combustible Liquids
wgk_germany
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Ning Luan et al.
Toxins, 11(12) (2019-12-11)
Elastase is a globular glycoprotein and belongs to the chymotrypsin family. It is involved in several inflammatory cascades on the basis of cleaving the important connective tissue protein elastin, and is strictly regulated to a balance by several endogenous inhibitors.
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