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444221

Sigma-Aldrich

MMP-1/MMP-9 Substrate, Fluorogenic

An excellent quenched fluorescence substrate for MMP-1 and MMP-9.

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Synonym(s):
MMP-1/MMP-9 Substrate, Fluorogenic
Empirical Formula (Hill Notation):
C49H68N14O12S
Molecular Weight:
1077.22

Quality Level

assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
protect from light

color

yellow

solubility

50% acetic acid: 10 mg/mL

fluorescence

λex ~365 nm
λem ~450 nm

shipped in

ambient

storage temp.

−20°C

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444215444212539149
Sigma-Aldrich

444221

MMP-1/MMP-9 Substrate, Fluorogenic

Sigma-Aldrich

444212

MMP-2 Substrate, Fluorogenic

form

solid

form

solid

form

lyophilized solid

form

solid

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

solubility

50% acetic acid: 10 mg/mL

solubility

DMSO: soluble

solubility

DMSO: 10 mg/mL

solubility

DMSO: 200 mg/mL, 80% acetic acid: 50 mg/mL, methanol: soluble

General description

An excellent quenched fluorescence substrate for MMP-1 and MMP-9 (excitation maximum: 365 nm; emission maximum: 450 nm). Both enzymes cleave this substrate between Gly and Cys(Me), liberating a fluorescent cleavage product. Suitable for inhibitor screening and determining Ki values. Excitation max: ~365 nm; emission max: ~450 nm.
An excellent quenched fluorescence substrate for MMP-1 and MMP-9. Both enzymes cleave this substrate between Gly and Cys(Me), liberating a fluorescent cleavage product. Suitable for inhibitor screening and determining Ki values.

Biochem/physiol Actions

Cell permeable: no
Primary Target
MMP-1, MMP-9
Product does not compete with ATP.
Reversible: no

Packaging

Packaged under inert gas

Warning

Toxicity: Standard Handling (A)

Sequence

{DNP-Pro-Cha-Gly-Cys(Me)-His-Ala-Lys(N-Me-Abz)-NH₂[Cha = β-cyclohexylalanyl; Abz = 2-aminobenzoyl (anthraniloyl)]

Other Notes

Bickett, D.M., et al. 1993. Anal. Biochem. 212, 58.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


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