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444235-M

Millipore

MMP-13 Substrate, Fluorogenic

A quenched fluorescence substrate for MMP-13 (collagenase-3; kcat/Km = 1.09 x 10⁶ M⁻¹s⁻¹).

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Synonym(s):
MMP-13 Substrate, Fluorogenic, Collagenase-3 Substrate, Fluorogenic
Empirical Formula (Hill Notation):
C51H65N13O15
Molecular Weight:
1100.14

Quality Level

assay

≥98% (HPLC)

form

lyophilized solid

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
desiccated
protect from light

color

yellow

solubility

DMSO: 5 mg/mL

fluorescence

λex ~325 nm
λem ~393 nm

storage temp.

−20°C

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444235-M

MMP-13 Substrate, Fluorogenic

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444212

MMP-2 Substrate, Fluorogenic

vibrant-m

444258

MMP-14 Substrate I, Fluorogenic

form

lyophilized solid

form

lyophilized solid

form

lyophilized solid

form

amorphous solid

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage condition

OK to freeze, protect from light, desiccated

storage condition

OK to freeze, desiccated, protect from light

storage condition

OK to freeze, protect from light

storage condition

OK to freeze, protect from light

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

General description

A quenched fluorescence substrate for MMP-13 (collagenase-3; kcat/Km = 1.09 x 106 M-1s-1). Less efficient as a substrate for MMP-1 (fibroblast collagenase) or MMP-8 (neutrophil collagenase).
A quenched fluorescence substrate for MMP-13 (collagenase-3; kcat/Km = 1.09 x 106 M-1s-1; excitation maximum: ~325 nm; emission maximum: ~393 nm). Less efficient as a substrate for MMP-1 (fibroblast collagenase) or MMP-8 (neutrophil collagenase).

Biochem/physiol Actions

Primary Target
A quenched fluorescence substrate for MMP-13 (collagenase-3)
kcat/Km = 1.09 x 106 M⁻¹ sec⁻¹ for MMP-13 (collagenase-3)

Warning

Toxicity: Standard Handling (A)

Sequence

MCA-Pro-Cha-Gly-Nva-His-Ala-Dpa-NH₂ [Cha = L-cyclohexylalanine; Dpa = 3-(2,4-dinitrophenyl)-L-2,3-diaminopropionyl; Nva = L-norvaline]

Physical form

Supplied as a trifluoroacetate salt.

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Knauper, V., et al. 1996. J. Biol. Chem. 271, 1544.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

11 - Combustible Solids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable


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