484100

5-Nitro-2-(3-phenylpropylamino)benzoic Acid

Potent Cl⁻ channel blocker (IC₅₀ = 100 nM-100 µM), depending on channel subtype and assay method.

• Synonym(s): 5-Nitro-2-(3-phenylpropylamino)benzoic Acid, NPPB, CaCC Blocker II, Calcium-Activated, TMEM16 Blocker II, ANO Blocker II, Anoctamin Blocker II
• Empirical Formula (Hill Notation): C₁₆H₁₆N₂O₄
• CAS Number: 107254-86-4
• Molecular Weight: 300.31
• MDL number: MFCD00153851
• UNSPSC Code: 51111800
• NACRES: NA.77

Properties

• Quality Level: 100
• assay: ≥98% (HPLC)
• form: solid
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze
• color: yellow
• solubility: DMSO: 5 mg/mL; warm ethanol: soluble
• shipped in: ambient
• storage temp.: 10-30°C
• InChI: 1S/C16H16N2O4/c19-16(20)14-11-13(18(21)22)8-9-15(14)17-10-4-7-12-5-2-1-3-6-12/h1-3,5-6,8-9,11,17H,4,7,10H2,(H,19,20)
• InChI key: WBSMIPAMAXNXFS-UHFFFAOYSA-N

Description

General description

Potent Cl^– channel blocker (IC₅₀ = 100 nM-100 µM), depending on channel subtype and assay method. Inhibits cyclooxygenase (IC₅₀ = 8 µM).

Potent Cl^- channel blocker (IC₅₀ = 100 nM-100 µM), depending on channel subtype and assay method. Inhibits cyclooxygenase (IC₅₀ = 8 µM).

Biochem/physiol Actions

Cell permeable: no

Primary Target
Cl⁻ channel blocker

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 100 nM-100 µM as Cl-channel blocker

Warning

Toxicity: Standard Handling (A)

Other Notes

Illek, B., et al. 1992. Am. J. Physiol.263, C644.
Kirk, K., et al. 1992. J. Biol. Chem.267, 23475.
Breuer, W., et al. 1989. Biochem. Biophys. Res. Commun.163, 398.
Wangermann, P., et al. 1986. Pflugers Arch.407, S128.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable