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I2636

Sigma-Aldrich

IgA from human colostrum

reagent grade, buffered aqueous solution

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Synonym(s):
Human IgA
MDL number:
NACRES:
NA.46

conjugate

unconjugated

Quality Level

grade

reagent grade

form

buffered aqueous solution

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

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1 of 4

This Item
I1010I2511I8640
vibrant-m

I2636

IgA from human colostrum

vibrant-m

I1010

IgA from human colostrum

vibrant-m

I2511

IgG from human serum

vibrant-m

I8640

IgG from human serum

form

buffered aqueous solution

form

essentially salt-free, lyophilized powder

form

buffered aqueous solution

form

buffered aqueous solution

shipped in

dry ice

shipped in

-

shipped in

dry ice

shipped in

dry ice

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

−20°C

grade

reagent grade

grade

reagent grade

grade

reagent grade

grade

technical grade

target post-translational modification

unmodified

target post-translational modification

-

target post-translational modification

unmodified

target post-translational modification

unmodified

General description

Immunoglobulin A (IgA) is the most abundant antibody isotype produced in humans. IgAs are heterogeneous and exist astwo IgA subtypes. It has the ability to form multimers by interacting with the joining (J) chain. It is present in large quantities in blood. Immunoglobulin A (IgA) antibodies protect mucosal surfaces against invading pathogens.

Application

IgA from human colostrum has been used to find out percent cross-selectivity values for lactoferrin immunosensors versus several common proteins contained in milk and saliva. It has also been used in western blotting.
IgA from human colostrum is a suitable ELISA standard used to estimate the concentrations of IgA in human B cell culture supernatants and in human blood, colostrum and cord blood samples.

Biochem/physiol Actions

IgA antibody is secretory antibody and is present abundantly in mucous linings of gastrointestinal, respiratory and genitourinary tracts, tears, colostrum and saliva. Thus secretory IgA contributes to the humoral defense mechanism against the pathogens on mucosal surfaces.

Physical form

Solution in 0.01 M Tris-HCl, 0.1 M sodium chloride, pH 8.0, containing 15 mM sodium azide

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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Danielle E Baranova et al.
Pathogens & immunity, 5(1), 89-116 (2021-06-18)
In cholera epidemics, the spread of disease can easily outpace vaccine control measures. The advent of technologies enabling the expression of recombinant proteins, including antibodies, in the milk of transgenic animals raises the prospect of developing a self-administered and cost-effective
Further development of lactoferrin immunosensor (part III)
Campanella L, et al.
Journal of Pharmaceutical and Biomedical Analysis, 186-193 (2010)
Beom Jin Lim et al.
Yonsei medical journal, 52(4), 610-615 (2011-05-31)
Deposition of polymeric IgA1 in the kidney mesangium is the hallmark of IgA nephropathy, but the molecular mechanisms of IgA-mediated mesangial responses and inflammatory injuries remain poorly understood. We hypothesize that Toll-like receptor 4 (TLR4) is involved in IgA-induced mesangial
M Raux et al.
Journal of immunological methods, 222(1-2), 111-124 (1999-02-18)
Enzyme-linked immunosorbent assays (ELISA) were developed to test, in serum and mucosal samples, total IgG, total IgA, serum albumin, and anti-gp120 MN and anti-p24 LAI IgG and IgA levels. These ELISAs were optimized according to reagents and experimental conditions. Inter-
Tithipong Plangsangmas et al.
Animals : an open access journal from MDPI, 10(1) (2020-01-23)
Salivary immunoglobulin A (sIgA) has been proposed as a potential indicator of welfare for various species, including Asian elephants, and may be related to adrenal cortisol responses. This study aimed to distinguish circadian rhythm effects on sIgA in male and

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