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401098

Sigma-Aldrich

Human IgA, Plasma

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assay

≥95% (SDS-PAGE)

Quality Level

form

liquid

contains

≤0.1% sodium azide as preservative

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze
avoid repeated freeze/thaw cycles

isotype

IgA

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

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411423I1261M1421
vibrant-m

401098

Human IgA, Plasma

vibrant-m

M1421

IgA, Kappa from murine myeloma

shipped in

wet ice

shipped in

wet ice

shipped in

dry ice

shipped in

dry ice

manufacturer/tradename

Calbiochem®

manufacturer/tradename

Calbiochem®

manufacturer/tradename

-

manufacturer/tradename

-

isotype

IgA

isotype

IgG1

isotype

-

isotype

-

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

assay

≥95% (SDS-PAGE)

assay

-

assay

-

assay

≥90% (non-reduced, SDS-PAGE)

General description

Immunoglobulin A (IgA) is the most dominantly generated antibody isotype. They are majorly secreted in the intestinal mucosa. IgA is present in colostrum, serum, saliva, and nasal fluid. It exists in two isotypic forms namely: IgA1 and IgA2. It is generated as secretory IgA (sIgA) and serum IgA. Serum IgA is present in the dimeric form linked by disulfide bond with an additional J chain. sIgA occurs in a monomeric form with two heavy and two light chains.

Application

Human IgA, Plasma has been used in enzyme-linked immunosorbent assay (ELISA).

Biochem/physiol Actions

Immunoglobulin A (IgA) initiates the alternative pathway of the complement system to elicit protective functions. It facilitates antibody-dependent cell-mediated cytotoxicity (ADCC) by attaching to leukocytes. This interaction boosts microbial destruction. IgA performances the first line of defense in antigen clearance. It avoids proteolysis and hinders the uptake of viral, bacterial, or antigen attachment. It lowers inflammation aroused by the classical pathway complement activation.

Packaging

Please refer to vial label for lot-specific concentration.

Warning

Toxicity: Standard Handling (A)

Physical form

In 100 mM NaCl, 100 mM Tris-HCl, pH 8.0.

Preparation Note

Prepared from plasma that has been shown by certified tests to be nonreactive for HBsAg and for antibodies to HCV, HBc, HIV-1 and HIV-2.

Reconstitution

Following initial thaw, aliquot and freeze (-20°C).

Other Notes

Variables associated with assay conditions will dictate the proper working dilution.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

Storage Class

12 - Non Combustible Liquids

wgk_germany

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable


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International Journal of Immunogenetics null
Handbook of Human Immunology (2008)
Andrew J Macpherson et al.
Annual review of immunology, 36, 359-381 (2018-02-06)
IgA is the dominant immunoglobulin isotype produced in mammals, largely secreted across the intestinal mucosal surface. Although induction of IgA has been a hallmark feature of microbiota colonization following colonization in germ-free animals, until recently appreciation of the function of
The structure and function of human IgA.
M A Kerr
The Biochemical journal, 271(2), 285-296 (1990-10-15)

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