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I4036

Sigma-Aldrich

IgA from human serum

reagent grade, ≥95% (HPLC), buffered aqueous solution

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NACRES:
NA.41

conjugate

unconjugated

Quality Level

grade

reagent grade

Assay

≥95% (HPLC)

form

buffered aqueous solution

storage temp.

−20°C

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This Item
I2511401098I8260
IgA from human serum reagent grade, ≥95% (HPLC), buffered aqueous solution

Sigma-Aldrich

I4036

IgA from human serum

IgG from human serum reagent grade, ≥95% (HPLC), buffered aqueous solution

Sigma-Aldrich

I2511

IgG from human serum

Sigma-Aldrich

Sigma-Aldrich

401098

Human IgA, Plasma

IgM from human serum reagent grade, ~95% (HPLC), buffered aqueous solution

Sigma-Aldrich

I8260

IgM from human serum

form

buffered aqueous solution

form

buffered aqueous solution

form

liquid

form

buffered aqueous solution

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

2-8°C

conjugate

unconjugated

conjugate

unconjugated

conjugate

-

conjugate

unconjugated

grade

reagent grade

grade

reagent grade

grade

-

grade

reagent grade

General description

IgA is one of the most abundant antibody isotypes produced in the body. It is mainly secreted by plasma cells located in the lamina propria. There are two subtypes of IgA, IgA1 and IgA2 present primarily in the airways and colon, respectively.

Application

IgA from human serum has been used in enzyme-linked immunosorbent assay (ELISA) for anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-spike-receptor binding domain (RBD) antibody detection in blood samples.
Purified human IgA may be used to study its physiological and biological effects on processes such as inflammation, pathogen elimination, regulation of antibody-dependent-cell-mediated cytotoxicity (ADCC), modulation of phagocytosis, degranulation of eosinophils and basophils and modulation of respiratory burst activity.

Biochem/physiol Actions

IgA aids in inducing a defense mechanism against various viral pathogens such as rotavirus, poliovirus, influenza virus, and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It regulates excessive immune responses in inflammatory diseases. IgA also has the potential to trigger neutrophil recruitment for cell killing.

Physical form

Solution in 0.01 M Phosphate Buffer saline, pH 7.4, containing 15 mM sodium azide as a preservative.

Storage Class Code

12 - Non Combustible Liquids

WGK

nwg

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Isabella Quinti et al.
Frontiers in cellular and infection microbiology, 11, 655896-655896 (2021-04-24)
A large repertoire of IgA is produced by B lymphocytes with T-independent and T-dependent mechanisms useful in defense against pathogenic microorganisms and to reduce immune activation. IgA is active against several pathogens, including rotavirus, poliovirus, influenza virus, and SARS-CoV-2. It
Development of a Duplex Serological Multiplex Assay for the Simultaneous Detection of Epstein-Barr Virus IgA and IgG Antibodies in Nasopharyngeal Carcinoma Patients.
Schieber, et al.
Cancers, 15 (2023)
Andrea Reboldi et al.
Science (New York, N.Y.), 352(6287), aaf4822-aaf4822 (2016-05-14)
Immunoglobulin A (IgA) induction primarily occurs in intestinal Peyer's patches (PPs). However, the cellular interactions necessary for IgA class switching are poorly defined. Here we show that in mice, activated B cells use the chemokine receptor CCR6 to access the
Hans Verkerke et al.
Journal of clinical microbiology, 59(4) (2021-01-21)
Accurate diagnosis of acute severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is critical for appropriate management of patients with this disease. We examined the possible complementary role of laboratory-developed class-specific clinical serology in assessing SARS-CoV-2 infection in hospitalized patients.
Rafael D Melani et al.
medRxiv : the preprint server for health sciences (2021-07-17)
Methods of antibody detection are used to assess exposure or immunity to a pathogen. Here, we present Ig-MS , a novel serological readout that captures the immunoglobulin (Ig) repertoire at molecular resolution, including entire variable regions in Ig light and

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