5.08316

CTAP

• Synonym(s): CTAP, µ opioid receptor antagonist, CTAP
• Empirical Formula (Hill Notation): C₅₁H₆₉N₁₃O₁₁S₂
• CAS Number: 103429-32-9
• Molecular Weight: 1104.30
• MDL number: MFCD00671434
• UNSPSC Code: 12352200
• NACRES: NA.77

Properties

• assay: ≥95% (HPLC)
• Quality Level: 100
• form: solid
• potency: 3.5 nM IC₅₀
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: off-white
• solubility: water: soluble
• storage temp.: −20°C
• InChI: 1S/C51H69N13O11S2/c1-26(65)39(42(53)68)62-49(75)41-51(3,4)77-76-25-38(61-43(69)33(52)21-28-11-6-5-7-12-28)47(73)59-36(22-29-16-18-31(67)19-17-29)45(71)60-37(23-30-24-57-34-14-9-8-13-32(30)34)46(72)58-35(15-10-20-56-50(54)55)44(70)63-40(27(2)66)48(74)64-41/h5-9,11-14,16-19,24,26-27,33,35-41,57,65-67H,10,15,20-23,25,52H2,1-4H3,(H2,53,68)(H,58,72)(H,59,73)(H,60,71)(H,61,69)(H,62,75)(H,63,70)(H,64,74)(H4,54,55,56)/t26-,27-,33-,35+,36+,37-,38+,39+,40+,41-/m1/s1
• InChI key: OFMQLVRLOGHAJI-FGHAYEPSSA-N

Description

General description

A highly potent octapeptide that acts as a selective and brain penetrating bioavailable µ opioid receptor antagonist (IC₅₀ = 3.5 nM). Used in studies of reward systems and additions.

Biochem/physiol Actions

Primary Target
u Opioid receptpr

Warning

Toxicity: Standard Handling (A)

Sequence

D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH2 (2-7 disulfide bond)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Perry, C., et al., 2013. Behav. Neurosci.127, 535.
Burkett, J. et al. 2011. Neuropsychopharm.36, 2200.
Steinmiller, L., et al., 2008. Psychopharmacol. (Berl).195, 497.
Sterious, S., et al., 2003. J. Pharmacol. Exp. Ther.304, 301.
Abbruscato, T., et al. 1997. J. Pharmacol.280, 402.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable