Skip to Content
MilliporeSigma
All Photos(1)

Documents

C2901

Sigma-Aldrich

Cholecystokinin (CCK) Fragment 26-33 Amide, Non-sulfated

≥95% (HPLC), powder

Sign Into View Organizational & Contract Pricing
All Photos(1)
Synonym(s):
CCK-8, non-sulfated
Empirical Formula (Hill Notation):
C49H62N10O13S2
CAS Number:
25679-24-7
Molecular Weight:
1063.21
MDL number:
MFCD00076488
UNSPSC Code:
12352200
PubChem Substance ID:
24892546
NACRES:
NA.32

Quality Level

200

assay

≥95% (HPLC)

form

powder

UniProt accession no.

P06307

storage temp.

−20°C

SMILES string

CSCCC(NC(=O)C(Cc1ccc(O)cc1)NC(=O)C(N)CC(O)=O)C(=O)NCC(=O)NC(Cc2c[nH]c3ccccc23)C(=O)NC(CCSC)C(=O)NC(CC(O)=O)C(=O)NC(Cc4ccccc4)C(N)=O

InChI

1S/C49H62N10O13S2/c1-73-18-16-34(55-47(70)37(21-28-12-14-30(60)15-13-28)58-44(67)32(50)23-41(62)63)45(68)53-26-40(61)54-38(22-29-25-52-33-11-7-6-10-31(29)33)48(71)56-35(17-19-74-2)46(69)59-39(24-42(64)65)49(72)57-36(43(51)66)20-27-8-4-3-5-9-27/h3-15,25,32,34-39,52,60H,16-24,26,50H2,1-2H3,(H2,51,66)(H,53,68)(H,54,61)(H,55,70)(H,56,71)(H,57,72)(H,58,67)(H,59,69)(H,62,63)(H,64,65)

InChI key

OIXQINQYMGNCII-UHFFFAOYSA-N

Gene Information

human ... CCK(885)

Looking for similar products? Visit Product Comparison Guide

Amino Acid Sequence

Asp-Tyr-Met-Gly-Trp-Met-Asp-Phe-NH2

Application

Cholecystokinin (CCK) Fragment 26-33 Amide, Non-sulfated has been used in the specificity testing against gastrin and pepsinogen I proteins.

Biochem/physiol Actions

Biologically inactive form of CCK-8; CCKB/gastrin receptor agonist that has no activity at the CCKA receptor.
Cholecystokinin (CCK) is a 115 amino acid preprohormone and a neurotransmitter. It exists in many isoforms. The octapeptide of CCK (CCK-8S) is the most abundant form. CCK is mapped to human chromosome 3p22.1. CCK interacts with receptors of the gastrointestinal tract and nervous system. Polymorphisms in the CCK is implicated in hallucinations in patients with Parkinson′s disease. CCK plays a key role in the activation of the calcineurin-regulated nuclear factor of activated T-cells (NFATs).

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Customers Also Viewed

Slide 1 of 2

1 of 2

Sigma-Aldrich

Sigma-Aldrich

96992

Cell Counting Kit - 8

[Leu15]-Gastrin I human ≥95% (HPLC)

Sigma-Aldrich

G9145

[Leu15]-Gastrin I human

Advances in molecular genetics of panic disorder.
Maron E, et al.
Molecular Psychiatry, 15(7), 681-681 (2010)
Atrophic gastritis serum levels of amidated gastrin-17 and pepsinogen I in atrophic gastritis: an observational case-control study.
Sipponen P, et al.
Scandinavian Journal of Gastroenterology, 37(7), 785-791 (2002)
Neuropeptide regulation of fear and anxiety: Implications of cholecystokinin, endogenous opioids, and neuropeptide γ.
Bowers ME, et al.
Physiology & Behavior, 107(5), 699-710 (2012)
Genetic substrates of psychosis in patients with Parkinson's disease: a critical review.
Lenka A, et al.
Journal of the Neurological Sciences, 364(5), 33-41 (2016)
J C Reubi et al.
Cancer research, 57(7), 1377-1386 (1997-04-01)
Cholecystokinin (CCK)-A and CCK-B/gastrin receptors were evaluated with in vitro receptor autoradiography in 406 human tumors of various origins using a sulfated 125I-labeled CCK decapeptide analogue 125I-(D-Tyr-Gly, Nle28,3l)-CCK 26-33 and 125I-labeled Leu15-gastrin as radioligands. CCK-B/gastrin receptors were found frequently in
View All Related Papers

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service