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T6515

Sigma-Aldrich

Cholecystokinin Fragment 30-33 Amide

≥95% (HPLC)

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Synonym(s):
CCK-4, Gastrin Tetrapeptide, Tetragastrin, Trp-Met-Asp-Phe amide
Empirical Formula (Hill Notation):
C29H36N6O6S
CAS Number:
Molecular Weight:
596.70
MDL number:
PubChem Substance ID:
NACRES:
NA.32

Quality Level

Assay

≥95% (HPLC)

form

powder

technique(s)

toxicology assay: suitable

UniProt accession no.

storage temp.

−20°C

SMILES string

CSCC[C@H](NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc3ccccc3)C(N)=O

InChI

1S/C29H36N6O6S/c1-42-12-11-22(33-27(39)20(30)14-18-16-32-21-10-6-5-9-19(18)21)28(40)35-24(15-25(36)37)29(41)34-23(26(31)38)13-17-7-3-2-4-8-17/h2-10,16,20,22-24,32H,11-15,30H2,1H3,(H2,31,38)(H,33,39)(H,34,41)(H,35,40)(H,36,37)/t20-,22-,23-,24-/m0/s1

InChI key

RGYLYUZOGHTBRF-BIHRQFPBSA-N

Gene Information

human ... CCK(885)
rat ... Cckbr(25706)

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This Item
C2175C2901C2581
form

powder

form

powder

form

powder

form

-

technique(s)

toxicology assay: suitable

technique(s)

-

technique(s)

-

technique(s)

competitive inhibition ELISA: 1:1000-1:2000, immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:8,000 using indirect immunoperoxidase staining of human stomach

UniProt accession no.

P06307, P30553

UniProt accession no.

P06307, P30551, P30553

UniProt accession no.

P06307

UniProt accession no.

P06307

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

Gene Information

human ... CCK(885)
rat ... Cckbr(25706)

Gene Information

human ... CCK(885)
rat ... Cckar(24889), Cckbr(25706)

Gene Information

human ... CCK(885)

Gene Information

human ... CCK(885)

Amino Acid Sequence

Trp-Met-Asp-Phe-NH2

Application

Cholecystokinin Fragment 30-33 Amide can be used for inactivating the CCK8 antiserum. The product can also be used as an antigen utilized in absorption control for testing the specificity of antisera.

Biochem/physiol Actions

Cholecystokinin Fragment 30-33 Amide also referred to as CCK-4 or Trp-Met-Asp-Phe amide is a peptide fragment derived from peptide hormone cholecystokinin. CCK-4 is a panicogenic agent that induces panic attacks in humans. This property of the compound can be used in scientific research for testing the new anxiolytic drugs.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Preparation Note

Cholecystokinin Fragment 30-33 Amide dissolves in Dimethylformamide at 20 mg/ml to yield a clear, colorless to yellow solution.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Andreas Ströhle et al.
Journal of psychiatric research, 43(12), 1013-1017 (2009-03-18)
Regular physical activity is anxiolytic in both healthy subjects and patients with panic disorder. In contrast, acute exercise may induce acute panic attacks or increase subjective anxiety in patients with panic disorder more than in other people. The effects of
Thérèse Schunck et al.
Journal of psychopharmacology (Oxford, England), 25(1), 52-59 (2010-05-26)
Benzodiazepine effects on cholecystokinin tetrapeptide (CCK-4)-induced panic attack (PA) in humans are incompletely characterized, in particular on the neurofunctional level. This work explores the effects of lorazepam on brain activity and behavioral and physiological symptoms related to CCK-4-induced PA in
Diana Koszycki et al.
Peptides, 35(1), 9-13 (2012-03-15)
Recent investigations suggest that genes that confer risk for panic disorder (PD) may moderate response to panicogenic agents in healthy volunteers. Given the potential role of the central cholecystokinin receptor (CCKBR) (CT) polymorphism alleles 26 and 27 in PD, the
A C Dieler et al.
Current pharmaceutical design, 14(33), 3492-3507 (2008-12-17)
Pharmacological magnetic resonance imaging (phMRI) is a method to study effects of psychopharmacological agents on neural activation. Changes of the blood oxygen level dependent (BOLD), the basis of functional MRI (fMRI), are typically obtained at relatively high sampling frequencies. This
Toyokazu Akimori et al.
Medical molecular morphology, 44(1), 7-14 (2011-03-23)
The function of brush cells is obscure, but recent cytochemical studies indicate that rat bile duct brush cells secrete NaHCO(3). The aim of this study was to determine the quantitative distribution of brush cells at 16 sites of the rat

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