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579000

Sigma-Aldrich

Tamoxifen Citrate

Tamoxifen is a potent synthetic anti-estrogenic agent.

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Synonym(s):
Tamoxifen Citrate, Estrogen Receptor Signaling Regulator I
Empirical Formula (Hill Notation):
C26H29NO · xC6H8O7
CAS Number:
Molecular Weight:
371.51 (salt-free basis)
MDL number:

Quality Level

assay

≥99% (HPLC)

form

powder

manufacturer/tradename

Calbiochem®

storage condition

OK to freeze

color

white to off-white

solubility

ethanol: 5 mg/mL
methanol: 5 mg/mL
water: sparingly soluble

shipped in

ambient

storage temp.

2-8°C

InChI

1S/C26H29NO.C6H8O7/c1-4-25(21-11-7-5-8-12-21)26(22-13-9-6-10-14-22)23-15-17-24(18-16-23)28-20-19-27(2)3;7-3(8)1-6(13,5(11)12)2-4(9)10/h5-18H,4,19-20H2,1-3H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/b26-25-;

InChI key

FQZYTYWMLGAPFJ-OQKDUQJOSA-N

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This Item
PHR2706T9262BP1225
vibrant-m

579000

Tamoxifen Citrate

vibrant-m

PHR2706

Tamoxifen Citrate

vibrant-m

T9262

Tamoxifen citrate salt

vibrant-m

BP1225

Tamoxifen citrate

Quality Level

100

Quality Level

300

Quality Level

200

Quality Level

100

assay

≥99% (HPLC)

assay

-

assay

≥99%

assay

-

manufacturer/tradename

Calbiochem®

manufacturer/tradename

-

manufacturer/tradename

-

manufacturer/tradename

BP

solubility

ethanol: 5 mg/mL, water: sparingly soluble, methanol: 5 mg/mL

solubility

-

solubility

methanol: soluble 50 mg/mL, clear, colorless

solubility

-

storage condition

OK to freeze

storage condition

-

storage condition

-

storage condition

-

General description

A potent synthetic anti-estrogen. A cell-permeable and reversible inhibitor of protein kinase C (IC50 = 10 µM). Induces apoptosis in human malignant glioma cell lines.
A potent synthetic anti-estrogenic agent. A cell-permeable and reversible inhibitor of protein kinase C (IC50 = 10 µM). Induces apoptosis in human malignant glioma cell lines and inhibits prostate cancer cell growth by induction of p21 protein.

Biochem/physiol Actions

Cell permeable: yes
Primary Target
PKC
Product does not compete with ATP.
Reversible: yes
Target IC50: 10 µM against protein kinase C

Warning

Toxicity: Harmful & Carcinogenic / Teratogenic (E)

Reconstitution

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Rohlff, C., et al. 1998. Prostate 37, 51.
Couldwell, W.J., et al. 1994. FEBS Lett.345, 43.
Baltuch, G.H., et al. 1993. Neurosurgery33, 495.
Powis, G. 1991. Trends Pharmacol. Sci.12, 188.
Issandou, M., et al. 1990. Cancer Res.50, 5845.
O’Brian, C.A., et al. 1985. Cancer Res.45, 2462.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

signalword

Danger

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1B - Repr. 1B

Storage Class

6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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