8.22324

1,2-Propanediol

EMPLURA^®

• Synonym(s): 1,2-Propanediol, 1,2-Propylene glycol
• Linear Formula: CH₃CH(OH)CH₂OH
• CAS Number: 57-55-6
• Molecular Weight: 76.09
• MDL number: MFCD00064272
• UNSPSC Code: 12352104
• EC Index Number: 200-338-0
• NACRES: NB.21

Properties

• vapor pressure: 0.11 hPa ( 20 °C)
• Quality Level: 200
• product line: EMPLURA^®
• assay: ≥99% (GC)
• form: liquid
• autoignition temp.: 371 °C
• potency: 19400-36000 mg/kg LD₅₀, oral (Rat); 20800 mg/kg LD₅₀, skin (Rabbit)
• expl. lim.: 2.4-17.4 % (v/v)
• impurities: ≤0.2% Water
• refractive index: n20/D 1.43
• pH: 6-8 (20 °C, 100 g/L in H₂O)
• bp: 188 °C/1013 hPa
• mp: -59 °C
• transition temp: flash point 99 °C
• density: 1.04 g/cm³ at 20 °C
• storage temp.: 2-30°C
• InChI: 1S/C3H8O2/c1-3(5)2-4/h3-5H,2H2,1H3
• InChI key: DNIAPMSPPWPWGF-UHFFFAOYSA-N

Description

Application

• (1)H-NMR metabolomics investigation of CSF from children with HIV reveals altered neuroenergetics due to persistent immune activation.: This research uses 1,2-Propanediol in metabolic profiling to study CSF in children with HIV, identifying neuroenergetic alterations due to persistent immune activation (Thirion et al., 2024).


• Insight into the influence of natural deep eutectic solvents on the extraction of phenolic compounds from poplar type propolis: Composition and in vitro biological activity.: The study explores using 1,2-Propanediol-based deep eutectic solvents for extracting phenolic compounds from propolis, assessing their composition and biological activity (Trusheva et al., 2024).


• In Silico-Assisted Isolation of trans-Resveratrol and trans-e-Viniferin from Grapevine Canes and Their Sustainable Extraction Using Natural Deep Eutectic Solvents (NADES).: This publication discusses the application of 1,2-Propanediol in the green chemistry extraction of valuable compounds from grapevines using computational and experimental methods (Kiene et al., 2023).


• Untargeted metabolomics provide new insights into the implication of Lactobacillus helveticus strains isolated from natural whey starter in methylglyoxal-mediated browning.: Research utilizing 1,2-Propanediol in metabolomic studies to understand the metabolic pathways influenced by Lactobacillus strains in dairy products (Galimberti et al., 2023).


• Milk oligosaccharide-driven persistence of Bifidobacterium pseudocatenulatum modulates local and systemic microbial metabolites upon synbiotic treatment in conventionally colonized mice.: A study focusing on the role of 1,2-Propanediol in modulating microbial metabolites through synbiotic treatments, impacting gut microbiota and systemic health (Larke et al., 2023).

Analysis Note

Purity (GC): ≥ 99.0 %
Identity (IR): conforms
Density (d 20 °C/ 4 °C): 1.036 - 1.037
Water: ≤ 0.20 %

Legal Information

EMPLURA is a registered trademark of Merck KGaA, Darmstadt, Germany

Safety Information

• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 1
• flash_point_f: 219.2 °F - closed cup
• flash_point_c: 104 °C - closed cup