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AB5905

Sigma-Aldrich

Anti-Vesicular Glutamate Transporter 1 Antibody

serum, Chemicon®

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Synonym(s):
VGLUT1, BNPI
eCl@ss:
32160702
NACRES:
NA.41

biological source

guinea pig

Quality Level

antibody form

serum

antibody product type

primary antibodies

clone

polyclonal

species reactivity

rat

manufacturer/tradename

Chemicon®

technique(s)

immunohistochemistry: suitable

NCBI accession no.

UniProt accession no.

shipped in

dry ice

target post-translational modification

unmodified

Gene Information

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This Item
MAB5502V0389V2514
biological source

guinea pig

biological source

mouse

biological source

rabbit

biological source

rabbit

antibody form

serum

antibody form

purified immunoglobulin

antibody form

IgG fraction of antiserum

antibody form

IgG fraction of antiserum

species reactivity

rat

species reactivity

mouse

species reactivity

human

species reactivity

rat

UniProt accession no.

Q62634

UniProt accession no.

Q62634

UniProt accession no.

Q9P2U7

UniProt accession no.

Q9JI12

shipped in

dry ice

shipped in

wet ice

shipped in

dry ice

shipped in

dry ice

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General description

Vesicular glutamate transporter 1 (VGLUT1) is encoded by the gene mapped to human chromosome 19q13. VGLUT1 is specifically expressed in neuronal cells in the brain. It is characterized with a conserved C-terminal dileucine-like motif and two polyproline domains distal to C- terminal end, including one that binds to endocytic BAR (Bin/Amphiphysin/Rvs) domain protein, endophilin.

Specificity

Recognizes Vesicular Glutamate Transporter 1 (VGLUT1, BNPI {Brain specific Na+ dependent inorganic phosphate cotransporter}). The antiserum has been tested on tissue sections from the rat central nervous system (CNS) using immunofluorescence histochemistry. The antiserum mainly labels nerve fibers and terminals. VGLUT1 is an excellent marker for glutamatergic nerve terminals. The staining pattern for the staining obtained with the VGLUT1 antiserum corresponds to the pattern described using other antisera to VGLUT1 (Bellocchio et al., 1998; Fremeau et al., 2001; Fujiyama et al., 2001; Sakata-Haga et al., 2001; Tong et al., 2001; Kaneko et al. 2002; Varoqui et al., 2002). Preabsorption of the VGLUT1 antiserum with immunogen peptide eliminates all immunostaining.

Immunogen

Synthetic peptide from rat VGLUT1 protein with no overlap to VGLUT2. The immunogen is available as AG208.

Application

  • Tested Applications

    Immunocytochemistry Analysis: A 1:250 dilution from a representative lot detected Vesicular Glutamate Transporter 1 in rat E18 cortical cells.
  • Note: Actual optimal working dilutions must be determined by end user as specimens, and experimental conditions may vary with the end user

Target description

62 kDa

Physical form

Guinea pig Serum in 0.1% Sodium Azide.

Legal Information

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Storage Class

10 - Combustible liquids

wgk_germany

WGK 1


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Depletion of spinal 5-HT accelerates mechanosensory recovery in the deafferented rat spinal cord
Cragg JJ, et al.
Experimental Neurology, 222(2), 277-284 (2010)
Assignment of SLC17A6 (alias DNPI), the gene encoding brain/pancreatic islet-type Na+-dependent inorganic phosphate cotransporter to human chromosome 11p14.3
Aihara Y, et al.
Cytogenetics and Cell Genetics (2001)
Lentiviral delivery of a vesicular glutamate transporter 1 (VGLUT1)-targeting short hairpin RNA vector into the mouse hippocampus impairs cognition
King MV, et al.
Neuropsychopharmacology, 39(2), 464-476 (2014)
Xia Chen et al.
PloS one, 6(2), e17072-e17072 (2011-03-02)
The success of transplants of neural tissue into the adult dentate gyrus in generating mature neurons is highly variable. Here we address the roles of the origin of the tissue and its pre-implantation preparation, and show that both are critical.
The regulation of corticofugal fiber targeting by retinal inputs
Grant E, et al.
Cerebral Cortex, 26(3), 1336-1348 (2016)

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