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P3088

Sigma-Aldrich

Monoclonal Anti-Parvalbumin antibody produced in mouse

clone PARV-19, ascites fluid

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Synonym(s):
Parvalbumin Antibody, Parvalbumin Antibody - Monoclonal Anti-Parvalbumin antibody produced in mouse
MDL number:
NACRES:
NA.44

biological source

mouse

Quality Level

conjugate

unconjugated

antibody form

ascites fluid

antibody product type

primary antibodies

clone

PARV-19, monoclonal

mol wt

antigen 12 kDa

contains

15 mM sodium azide

species reactivity

fish, frog, rabbit, canine, feline, bovine, pig, human, goat, rat

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:2,000 using formalin-fixed, paraffin-embedded rat tongue or cerebellum sections
indirect ELISA: suitable
western blot: suitable

isotype

IgG1

UniProt accession no.

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... PVALB(5816)
rat ... Pvalb(25269)

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M4403G3893A7811
clone

PARV-19, monoclonal

clone

HM-2, monoclonal

clone

G-A-5, monoclonal

clone

EA-53, monoclonal

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

Gene Information

human ... PVALB(5816)
rat ... Pvalb(25269)

Gene Information

human ... MAP2(4133)
mouse ... Mtap2(17756)
rat ... Map2(25595)

Gene Information

human ... GFAP(2670)
rat ... Gfap(24387)

Gene Information

human ... ACTN2(88)
mouse ... Actn2(11472)
rat ... Actn2(291245)

biological source

mouse

biological source

mouse

biological source

mouse

biological source

mouse

antibody form

ascites fluid

antibody form

ascites fluid

antibody form

ascites fluid

antibody form

ascites fluid

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General description

PVALB (parvalbumin) is a classical small member of the low molecular weight, acidic protein family known as calcium binding proteins (CaBPs) EF-hand superfamily. This protein shows a restricted pattern of expression in brain and muscle. It is a cytoplasmic high affinity CaBP.
Monoclonal Anti-Parvalbumin (mouse IgG1 isotype) is derived from the PARV-19 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse. Parvalbumin is a calcium-binding protein.

Specificity

Recognizes parvalbumin in a Ca2+ ion-dependent manner. Does not react with other members of the EF-hand family such as calmodulin, intestinal calcium-binding protein, S100A2 (S100L), S100A6 (calcyclin), the α chain of S-100 (i.e. in S-100a and S-100ao), or the β chain (i.e. in S-100a and S-100b).

Immunogen

Frog muscle parvalbumin.

Application

Monoclonal Anti-Parvalbumin antibody produced in mouse has been used for immunohistochemistry, immunocytochemistry, and immunofluorescence.

Biochem/physiol Actions

PVALB (parvalbumin) protein modulates relaxation in fast contracting muscles, where it localizes to type II (fast-twitch) mammalian skeletal muscle fibres in small mammals. This protein is a crucial regulator of neuronal intracellular calcium dynamics. PVALB protein maintains synaptic transmission during bursts, where it prevents presynaptic Ca2+ accumulation and hence the harmful effects of excess presynaptic Ca2+ levels. It also maintains synaptic transmission by allowing for linear information processing post-synaptically by preventing cumulative neuronal facilitation.

PVALB (parvalbumin) expression serves as marker for differentiating tumors as benign and malignant, in relation with thyroid lesions. Decreased expression of parvalbumin positive interneurons in rat model is associated with schizophrenia, and is known to disturb neuronal activity.

Physical form

Liquid

Storage and Stability

For continuous use, store at 2-8 °C for up to one month.
For extended storage freeze in working aliquots. Repeated freezing and thawing is not recommended. Storage in "frost-free" freezers is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage Class

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable


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Aging-related changes in calcium-binding proteins in rat perirhinal cortex
Moyer Jr J R, et al.
Neurobiology of Aging, 32(9), 1693-1706 (2011)
Ultrastructural analysis of parvalbumin synapses in human dorsolateral prefrontal cortex.
Glausier J R, et al.
The Journal of Comparative Neurology, 525(9), 2075-2089 (2017)
Calcium-binding protein parvalbumin is associated with fast contracting muscle fibres.
Celio MR and Heizmann CW
Nature, 297(5866), 504-506 (1982)
Role of the calcium-binding protein parvalbumin in short-term synaptic plasticity.
Caillard O et al
Proceedings of the National Academy of Sciences of the USA, 97(24), 13372-13377 (2000)
PVALB diminishes [Ca2+] and alters mitochondrial features in follicular thyroid carcinoma cells through AKT/GSK3β pathway}
Mendes T B, et al.
Endocrine-Related Cancer, 23(9), 769-782 (2016)

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